groL protein (Clostridium saccharoperbutylacetonicum)

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groL

60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)

Predicted Functional Partners:

groS

0.999

grpE

0.994

dnaK

0.985

htpG

0.960

dnaJ_1

0.947

hscC_1

0.944

hscC_2

0.936

AQR94236.1

0.904

AQR98060.1

0.904

atpA

0.903

Your Current Organism:

Clostridium saccharoperbutylacetonicum

NCBI taxonomy Id: 36745
Other names: ATCC 27021, C. saccharoperbutylacetonicum, Clostridium saccharoperbutylacetonicum Keis et al. 2001, DSM 14923, NCIMB 12606, strain N1-4 (HMT)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR94236.1	atpA	CLSAP_15430	CLSAP_06250	Hypothetical protein.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	0.614
AQR94236.1	dnaJ_1	CLSAP_15430	CLSAP_09580	Hypothetical protein.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.817
AQR94236.1	groL	CLSAP_15430	CLSAP_04550	Hypothetical protein.	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.904
AQR94236.1	groS	CLSAP_15430	CLSAP_04540	Hypothetical protein.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.857
AQR94236.1	grpE	CLSAP_15430	CLSAP_09560	Hypothetical protein.	Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.905
AQR94236.1	htpG	CLSAP_15430	CLSAP_16040	Hypothetical protein.	Chaperone protein HtpG.	0.906
AQR98060.1	atpA	CLSAP_54110	CLSAP_06250	StbA protein.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	0.614
AQR98060.1	dnaJ_1	CLSAP_54110	CLSAP_09580	StbA protein.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.811
AQR98060.1	groL	CLSAP_54110	CLSAP_04550	StbA protein.	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.904
AQR98060.1	groS	CLSAP_54110	CLSAP_04540	StbA protein.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.857
AQR98060.1	grpE	CLSAP_54110	CLSAP_09560	StbA protein.	Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.905
AQR98060.1	htpG	CLSAP_54110	CLSAP_16040	StbA protein.	Chaperone protein HtpG.	0.906
atpA	AQR94236.1	CLSAP_06250	CLSAP_15430	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	Hypothetical protein.	0.614
atpA	AQR98060.1	CLSAP_06250	CLSAP_54110	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	StbA protein.	0.614
atpA	dnaJ_1	CLSAP_06250	CLSAP_09580	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.417
atpA	dnaK	CLSAP_06250	CLSAP_09570	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.644
atpA	groL	CLSAP_06250	CLSAP_04550	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.903
atpA	groS	CLSAP_06250	CLSAP_04540	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.658
atpA	hscC_1	CLSAP_06250	CLSAP_22640	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	Chaperone protein HscC; Belongs to the heat shock protein 70 family.	0.644
atpA	hscC_2	CLSAP_06250	CLSAP_23150	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.	Chaperone protein HscC; Belongs to the heat shock protein 70 family.	0.644

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