| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| spo0A | spoIIAA | CLSAP_25020 | CLSAP_09330 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | 0.897 |
| spo0A | spoIIAB_1 | CLSAP_25020 | CLSAP_09340 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.937 |
| spo0A | spoIIE | CLSAP_25020 | CLSAP_01230 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage II sporulation protein E. | 0.922 |
| spo0A | spoIIGA | CLSAP_25020 | CLSAP_12260 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Sporulation sigma-E factor-processing peptidase; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | 0.812 |
| spo0A | spoIIIAA | CLSAP_25020 | CLSAP_24820 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Hypothetical protein. | 0.815 |
| spo0A | spoIIID | CLSAP_25020 | CLSAP_06330 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage III sporulation protein D. | 0.896 |
| spo0A | spoIIP | CLSAP_25020 | CLSAP_09440 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage II sporulation protein SpoIIP. | 0.822 |
| spo0A | spoIIR | CLSAP_25020 | CLSAP_06020 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage II sporulation protein SpoIIR. | 0.866 |
| spo0A | spoIVA | CLSAP_25020 | CLSAP_12420 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.854 |
| spo0A | spoIVB | CLSAP_25020 | CLSAP_25010 | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | SpoIVB peptidase precursor. | 0.940 |
| spoIIAA | spo0A | CLSAP_09330 | CLSAP_25020 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.897 |
| spoIIAA | spoIIAB_1 | CLSAP_09330 | CLSAP_09340 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.999 |
| spoIIAA | spoIIE | CLSAP_09330 | CLSAP_01230 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage II sporulation protein E. | 0.905 |
| spoIIAA | spoIIGA | CLSAP_09330 | CLSAP_12260 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Sporulation sigma-E factor-processing peptidase; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | 0.899 |
| spoIIAA | spoIIIAA | CLSAP_09330 | CLSAP_24820 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Hypothetical protein. | 0.607 |
| spoIIAA | spoIIID | CLSAP_09330 | CLSAP_06330 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage III sporulation protein D. | 0.822 |
| spoIIAA | spoIIP | CLSAP_09330 | CLSAP_09440 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage II sporulation protein SpoIIP. | 0.849 |
| spoIIAA | spoIIR | CLSAP_09330 | CLSAP_06020 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage II sporulation protein SpoIIR. | 0.880 |
| spoIIAA | spoIVA | CLSAP_09330 | CLSAP_12420 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.832 |
| spoIIAA | spoIVB | CLSAP_09330 | CLSAP_25010 | Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family. | SpoIVB peptidase precursor. | 0.757 |
