| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk_1 | pyrH | CLSAP_30650 | CLSAP_12960 | Cytidylate kinase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.826 |
| cmk_1 | rpiB | CLSAP_30650 | CLSAP_07200 | Cytidylate kinase. | Hypothetical protein. | 0.555 |
| fgs | glyA | CLSAP_32920 | CLSAP_25620 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.885 |
| fgs | gno | CLSAP_32920 | CLSAP_07190 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Gluconate 5-dehydrogenase. | 0.417 |
| fgs | pyrH | CLSAP_32920 | CLSAP_12960 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.428 |
| fgs | rpiB | CLSAP_32920 | CLSAP_07200 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Hypothetical protein. | 0.559 |
| glyA | fgs | CLSAP_25620 | CLSAP_32920 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.885 |
| glyA | nifJ_1 | CLSAP_25620 | CLSAP_30950 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Pyruvate-flavodoxin oxidoreductase. | 0.510 |
| glyA | pyrH | CLSAP_25620 | CLSAP_12960 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.410 |
| glyA | rpiB | CLSAP_25620 | CLSAP_07200 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein. | 0.533 |
| glyA | tpiA | CLSAP_25620 | CLSAP_48660 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.773 |
| gno | fgs | CLSAP_07190 | CLSAP_32920 | Gluconate 5-dehydrogenase. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.417 |
| gno | melR_1 | CLSAP_07190 | CLSAP_07180 | Gluconate 5-dehydrogenase. | Melibiose operon regulatory protein. | 0.688 |
| gno | rpe | CLSAP_07190 | CLSAP_12580 | Gluconate 5-dehydrogenase. | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.417 |
| gno | rpiB | CLSAP_07190 | CLSAP_07200 | Gluconate 5-dehydrogenase. | Hypothetical protein. | 0.927 |
| lacC | nifJ_1 | CLSAP_31030 | CLSAP_30950 | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Pyruvate-flavodoxin oxidoreductase. | 0.451 |
| lacC | rpiB | CLSAP_31030 | CLSAP_07200 | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Hypothetical protein. | 0.758 |
| lacC | tpiA | CLSAP_31030 | CLSAP_48660 | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.646 |
| melR_1 | gno | CLSAP_07180 | CLSAP_07190 | Melibiose operon regulatory protein. | Gluconate 5-dehydrogenase. | 0.688 |
| melR_1 | rpiB | CLSAP_07180 | CLSAP_07200 | Melibiose operon regulatory protein. | Hypothetical protein. | 0.527 |