| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dhfrIII | uppP | CLSAP_53740 | CLSAP_10870 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.777 |
| dhfrIII | ybhF_1 | CLSAP_53740 | CLSAP_17450 | Dihydrofolate reductase type 3; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Putative ABC transporter ATP-binding protein YbhF. | 0.639 |
| folA_1 | uppP | CLSAP_20990 | CLSAP_10870 | Dihydrofolate reductase. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.675 |
| folA_1 | ybhF_1 | CLSAP_20990 | CLSAP_17450 | Dihydrofolate reductase. | Putative ABC transporter ATP-binding protein YbhF. | 0.639 |
| folA_2 | uppP | CLSAP_47530 | CLSAP_10870 | Dihydrofolate reductase. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.675 |
| folA_2 | ybhF_1 | CLSAP_47530 | CLSAP_17450 | Dihydrofolate reductase. | Putative ABC transporter ATP-binding protein YbhF. | 0.639 |
| gmuF | uppP | CLSAP_10860 | CLSAP_10870 | Putative mannose-6-phosphate isomerase GmuF. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.592 |
| ispU | mraY | CLSAP_14510 | CLSAP_24480 | Ditrans,polycis-undecaprenyl-diphosphate synthase. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.508 |
| ispU | pyrG | CLSAP_14510 | CLSAP_06060 | Ditrans,polycis-undecaprenyl-diphosphate synthase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.667 |
| ispU | pyrH | CLSAP_14510 | CLSAP_12960 | Ditrans,polycis-undecaprenyl-diphosphate synthase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.739 |
| ispU | uppP | CLSAP_14510 | CLSAP_10870 | Ditrans,polycis-undecaprenyl-diphosphate synthase. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.983 |
| ispU | uppS | CLSAP_14510 | CLSAP_12980 | Ditrans,polycis-undecaprenyl-diphosphate synthase. | Ditrans,polycis-undecaprenyl-diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.913 |
| mraY | ispU | CLSAP_24480 | CLSAP_14510 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Ditrans,polycis-undecaprenyl-diphosphate synthase. | 0.508 |
| mraY | pyrH | CLSAP_24480 | CLSAP_12960 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.485 |
| mraY | uppP | CLSAP_24480 | CLSAP_10870 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.956 |
| mraY | uppS | CLSAP_24480 | CLSAP_12980 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Ditrans,polycis-undecaprenyl-diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.690 |
| pyrG | ispU | CLSAP_06060 | CLSAP_14510 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Ditrans,polycis-undecaprenyl-diphosphate synthase. | 0.667 |
| pyrG | pyrH | CLSAP_06060 | CLSAP_12960 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.899 |
| pyrG | uppP | CLSAP_06060 | CLSAP_10870 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.641 |
| pyrG | uppS | CLSAP_06060 | CLSAP_12980 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Ditrans,polycis-undecaprenyl-diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.720 |