| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| preA | pyrB | CLSAP_38850 | CLSAP_10900 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.902 |
| preA | pyrC | CLSAP_38850 | CLSAP_10920 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.988 |
| preA | pyrF | CLSAP_38850 | CLSAP_10930 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.939 |
| preA | pyrH | CLSAP_38850 | CLSAP_12960 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.478 |
| preA | pyrR | CLSAP_38850 | CLSAP_24620 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.971 |
| preA | udk_1 | CLSAP_38850 | CLSAP_08440 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Uridine kinase. | 0.480 |
| preA | upp | CLSAP_38850 | CLSAP_06160 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.939 |
| preA | uraA | CLSAP_38850 | CLSAP_25280 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Uracil permease. | 0.789 |
| pyrB | preA | CLSAP_10900 | CLSAP_38850 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | 0.902 |
| pyrB | pyrC | CLSAP_10900 | CLSAP_10920 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
| pyrB | pyrF | CLSAP_10900 | CLSAP_10930 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.982 |
| pyrB | pyrH | CLSAP_10900 | CLSAP_12960 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.533 |
| pyrB | pyrR | CLSAP_10900 | CLSAP_24620 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.983 |
| pyrB | upp | CLSAP_10900 | CLSAP_06160 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.776 |
| pyrB | uraA | CLSAP_10900 | CLSAP_25280 | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil permease. | 0.964 |
| pyrC | preA | CLSAP_10920 | CLSAP_38850 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | 0.988 |
| pyrC | pyrB | CLSAP_10920 | CLSAP_10900 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| pyrC | pyrF | CLSAP_10920 | CLSAP_10930 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.971 |
| pyrC | pyrH | CLSAP_10920 | CLSAP_12960 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.486 |
| pyrC | pyrR | CLSAP_10920 | CLSAP_24620 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.946 |