Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
purDCOG family:phosphoribosylamine-glycine ligase; GarS:glycinamide ribonucleotide synthetase;phosphoribosylglycinamide synthetase; Orthologue of BL1123; PFAM_ID: GARS; Belongs to the GARS family. (420 aa)    
Predicted Functional Partners:
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 0.999
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Catalyzes the formation of1-(5-phosphoribosyl)-5-aminoimidazole from2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP inpurine biosynthesis; Orthologue of BL1122.
 
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 0.999
purQ_purL
Phosphoribosylformylglycinamidine synthase; Bifunctional enzyme; Orthologue of CAC1655_BL1108.
 
 
 0.999
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate andL-aspartate in purine biosynthesis; Orthologue of BL1107; Belongs to the SAICAR synthetase family.
  
 0.992
purB
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novosynthesis of purines: the cleavage of adenylosuccinate andsuccinylaminoimidazole carboxamide ribotide; Orthologue of BL1800.
  
 0.983
purH
Bifunctional purine biosynthesis protein purH; Orthologue of BL0735.
 
 0.974
purT
Probable phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
  
 
 0.971
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.930
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.836
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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