Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (234 aa)    
Predicted Functional Partners:
pbuX
COG family: xanthine_uracil permeases; Orthologue of BL0892; PFAM_ID: xan_ur_permease.
  
 0.955
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 0.954
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.914
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.907
BAD_0777
GMP reductase; COG family: IMP dehydrogenase_GMP reductase; Orthologue of BL1500; PFAM_ID: IMPDH_C; PFAM_ID: IMPDH_N.
  
 
 0.879
hprT
COG family: hypoxanthine-guaninephosphoribosyltransferase; Orthologue of BL1681; PFAM_ID: Pribosyltran; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.876
BAD_0213
Possible amidotransferase; COG family: GMP synthase - glutamineamidotransferase domain; Orthologue of BL0300; PFAM_ID: GATase.
  
 
 0.865
BAD_0268
Hypothetical protein; COG family: uncharacterized Acr; Orthologue of BL0325; PFAM_ID: DUF152.
    
  0.860
purQ_purL
Phosphoribosylformylglycinamidine synthase; Bifunctional enzyme; Orthologue of CAC1655_BL1108.
 
  
 0.769
purB
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novosynthesis of purines: the cleavage of adenylosuccinate andsuccinylaminoimidazole carboxamide ribotide; Orthologue of BL1800.
  
 0.762
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.