Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (472 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase; Catalyzes the transfer of the carbamoyl moiety fromcarbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; Orthologue of BL0794; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.996
pyrK
Probable dihydroorotate dehydrogenase electron transfer subunit; COG family: 2-polyprenylphenolhydroxylase and related flavodoxin oxidoreductases; Orthologue of BL0790; PFAM_ID: FAD_binding_6.
 
 
 0.995
pyrI
Aspartate carbamoyltransferase regulatory chain; Catalyzes the transfer of the carbamoyl moiety fromcarbamoyl phosphate to L- aspartate in pyrimidinebiosynthesis; Involved in the allosteric regulation of aspartatecarbamoyltransferase; Orthologue of BL0793.
    
 0.986
carA
Composed of two chains; the small (or glutamine)chain promotes the hydrolysis of glutamine to ammonia_which is used by the large (or ammonia) chain tosynthesize carbamoyl phosphate; Orthologue of BL0067; Belongs to the CarA family.
  
 0.980
carB
Carbamoyl-phosphate synthase large chain; Composed of two chains; the small (or glutamine)chain promotes the hydrolysis of glutamine to ammonia_which is used by the large (or ammonia) chain tosynthesize carbamoyl phosphate; binds manganese; involvedin pyrimidine synthesis; Orthologue of Rv1384_BL0068.
 
 0.976
BAD_1334
Dihydroorotate dehydrogenase-like protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.971
BAD_0182
Hypothetical protein; COG family: dihydroorotate dehydrogenase; Orthologue of BL1265; PFAM_ID:DHOdehase.
 
 0.957
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.948
pyrF
COG family:orotidine-5'-phosphate decarboxylase; OMP decarboxylase; Orthologue of BL0791; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.939
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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