Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
icd1COG family: isocitrate dehydrogenases; Orthologue of BL1499; Oxalosuccinate decarboxylase; PFAM_ID: isodh; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)    
Predicted Functional Partners:
acn
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.982
gltA2
COG family: citrate synthase; Orthologue of BL1733; Belongs to the citrate synthase family.
  
 0.940
ldh2
L-lactate dehydrogenase 2; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.935
gltB
Glutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13).
    
 0.928
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
  
 0.909
gdhA
COG0334; Converts 2-oxoglutarate to glutamate; In Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; Leucine dehydrogenase; Orthologue of BL0630; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.907
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.885
purB
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novosynthesis of purines: the cleavage of adenylosuccinate andsuccinylaminoimidazole carboxamide ribotide; Orthologue of BL1800.
  
 
 0.872
sdhA
COG family: succinate dehydrogenase_fumaratereductase_ flavoprotein subunits; Orthologue of BL0938; PFAM_ID: FAD_binding_2; PFAM_ID: succ_DH_flav_C.
  
 
 0.869
BAD_0196
Probable aminotransferase; Catalyzes the formation of oxalozcetate andL-glutamate from L-aspartate and 2-oxoglutarate; Orthologue of BL0783.
   
 
 0.863
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.