Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
sucDsuccinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (307 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
BAD_0592
Probable iron sulfur protein associated with succinate dehydrogenase; COG family: succinate dehydrogenase_fumaratereductase Fe-S protein; Orthologue of BL0939; fumarate reductase.
 
 0.988
sdhA
COG family: succinate dehydrogenase_fumaratereductase_ flavoprotein subunits; Orthologue of BL0938; PFAM_ID: FAD_binding_2; PFAM_ID: succ_DH_flav_C.
 
 0.982
gltB
Glutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13).
  
 
 0.931
BAD_0319
Acetaldehyde dehydrogenase; Orthologue of ECs1741; Similar to ADHE_ECOLI gi|1787493 (conserved in Escherichia coli K-12); In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.909
gltA2
COG family: citrate synthase; Orthologue of BL1733; Belongs to the citrate synthase family.
  
 0.909
pta
Phosphate acetyltransferase; COG family:phosphotransacetylase; Orthologue of BL0968; PFAM_ID: PTA_PTB; Phosphotransacetylase.
  
 
 0.876
leuA
Possible TetR-type transcriptional regulator; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.873
BAD_0254
JadJ; COG family: biotin carboxylase; Orthologue of BL1535.
   
 
 0.862
pfl
Formate acetyltransferase; Orthologue of BL0951_HI0180.
     
 0.857
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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