Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BAD_0874Hypothetical protein; Orthologue of spr0628; Probable transcriptional regulator. (321 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase; COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113.
  
 
 0.965
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
    
 0.893
BAD_1078
Hypothetical protein; Orthologue of BL1364.
    
 0.870
BAD_1548
Alkaline phosphatase; Orthologue of ECs0433.
     
  0.856
thiE
Bifunctional protein thiEC; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 
 0.680
thiG
Thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.653
BAD_0090
Thiamine biosynthesis protein ThiF; Catalyzes the adenylation of ThiS which is involvedin the formation of 5-methyl-4-(beta-hydroxyethyl)thiazolephosphate; Orthologue of CAC2923.
  
  
 0.501
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the formation ofLL-2_6-diaminoheptanedioate and succinate fromN-succinyl-LL-2_6-diaminoheptanedioate; Orthologue of BL1280.
  
 
 0.423
BAD_0947
Widely conserved protein in peptidase or deacetlylase family; COG family: acetylornithinedeacetylase_succinyl-diaminopimelate desuccinylase andrelated deacylases; Orthologue of BL1072; PFAM_ID: Peptidase_M20.
  
 
 0.423
cbiO
Cobalt import ATP-binding/permease protein cbiO; COG family: ABC-type cobalt transport system_permease component CbiQ and related transporters; Orthologue of BL0043; PFAM_ID: CbiQ; PFAM_ID:ABC_tran.
  
  
 0.416
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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