Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa)    
Predicted Functional Partners:
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.999
gltB
Glutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13).
    
 0.926
glnA2
Glutamine synthetase 2; Orthologue of Tfu_0982_ BL1302; Belongs to the glutamine synthetase family.
     
 0.893
atpA
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
 
    
 0.870
gdhA
COG0334; Converts 2-oxoglutarate to glutamate; In Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; Leucine dehydrogenase; Orthologue of BL0630; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.869
glnA1
Glutamine synthetase 1; Orthologue of jk0702_BL1076.
     
 0.868
gltD
Glutamate synthase [NADPH] small subunit; COG family: NADPH-dependent glutamatesynthase beta chain and related oxidoreductases; Orthologue of BL0833; PFAM_ID: pyr_redox; PFAM_ID:FAD_binding_3.
    
 0.862
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.824
nadD
Possible nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
  
 0.803
BAD_0900
Hypothetical protein; Orthologue of BL1033.
       0.771
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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