Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)    
Predicted Functional Partners:
purH
Bifunctional purine biosynthesis protein purH; Orthologue of BL0735.
  
 0.981
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.977
folD
Bifunctional methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.975
purQ_purL
Phosphoribosylformylglycinamidine synthase; Bifunctional enzyme; Orthologue of CAC1655_BL1108.
  
 
 0.972
fhs
Formate-tetrahydrofolate ligase; COG family: formyltetrahydrofolate synthetase; Orthologue of BL0478; PFAM_ID:FTHFS; formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.964
sdaA
COG family: L-serinedeaminase; L-serine deaminase; Orthologue of BL1017.
  
 
 0.963
serB
COG family: phosphoserine phosphatase; Orthologue of BL1792; PFAM_ID:Hydrolase; Psp:O-phosphoserine phosphohydrolase.
  
 0.938
metF
COG family: 5_10-methylenetetrahydrofolatereductase; Orthologue of BL0797; PFAM_ID: MTHFR; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.935
cbsSV
Cystathionine beta-synthase; Beta-thionase; COGfamily: cysteine synthase; Orthologue of BL1156; PFAM_ID: PALP; serine sulfhydrase.
  
 
 0.934
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.933
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.