Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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ppnKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (314 aa)    
Predicted Functional Partners:
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.948
pntA
COG family: NAD_NADP transhydrogenase alphasubunit; Orthologue of BL0857; PFAM_ID: AlaDh_PNT; Pyridine nucleotide transhydrogenase subunit alpha1.
     
 0.935
nadD
Possible nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.904
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
 
   
 0.878
BAD_1569
Sir2-type regulatory protein; COG family: NAD-dependent protein deacetylases_Sir2 family; Orthologue of BL1528; PFAM_ID: SIR2.
  
 
 0.863
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.861
BAD_1346
Hypothetical protein; COG family: NTP pyrophosphohydrolases containing aZn-finger_ probably nucleic-acid-binding; Orthologue of BL1222; PFAM_ID: NUDIX.
     
  0.857
BAD_0906
Possible hydrolyase with Pf00702 domain; COG family: predicted phosphatase_phosphohexomutase; Orthologue of BL1042; PFAM_ID: Hydrolase.
       0.717
BAD_0910
Hypothetical protein; COG family: K+ transport systems_ NAD-bindingcomponent; Orthologue of BL1046; PFAM_ID: KTN; PFAM_ID: TrkA.
    
  0.679
dxs
Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
    
 0.674
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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