Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
pdhDCOG family: dihydrolipoamidedehydrogenase_glutathio ne oxidoreductase and relatedenzymes; Orthologue of BL1074; PFAM_ID: pyr_redox. (507 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.979
glnA1
Glutamine synthetase 1; Orthologue of jk0702_BL1076.
  
 
 0.929
gltB
Glutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13).
    
 0.926
gdhA
COG0334; Converts 2-oxoglutarate to glutamate; In Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; Leucine dehydrogenase; Orthologue of BL0630; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.913
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.883
folD
Bifunctional methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.882
metF
COG family: 5_10-methylenetetrahydrofolatereductase; Orthologue of BL0797; PFAM_ID: MTHFR; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.875
gltD
Glutamate synthase [NADPH] small subunit; COG family: NADPH-dependent glutamatesynthase beta chain and related oxidoreductases; Orthologue of BL0833; PFAM_ID: pyr_redox; PFAM_ID:FAD_binding_3.
    
 0.869
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.869
pfl
Formate acetyltransferase; Orthologue of BL0951_HI0180.
     
 0.868
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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