STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtCErgothioneine biosynthesis protein EgtC; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (258 aa)    
Predicted Functional Partners:
egtB
Sulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
 
 
 0.999
egtD
Dimethylhistidine N-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
 
 0.990
egtA
Ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
 
    0.960
OEJ34674.1
TIGR02452 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.793
OEJ34668.1
Dodecin family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.588
OEJ31438.1
Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.496
OEJ31460.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.496
OEJ31681.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.496
OEJ34578.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.496
OEJ34767.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.496
Your Current Organism:
Streptomyces subrutilus
NCBI taxonomy Id: 36818
Other names: ATCC 27467, BCRC 11921, CBS 689.72, CCRC 11921, CCRC:11921, DSM 40445, IFO 13388, ISP 5445, JCM 4695, JCM 4834, KCTC 9045, NBRC 13388, NRRL B-12377, NRRL-ISP 5445, S. subrutilus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.