Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABN57912.1PFAM: heat shock protein Hsp20; KEGG: mhu:Mhun_0154 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (156 aa)    
Predicted Functional Partners:
ABN57913.1
PFAM: CBS domain containing protein; ParB domain protein nuclease; KEGG: mhu:Mhun_2618 CBS.
     
 0.614
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.570
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.551
rpl10e
TIGRFAM: ribosomal protein L10.e; PFAM: Ribosomal protein L10E; KEGG: mhu:Mhun_0088 ribosomal protein L10.e; Belongs to the universal ribosomal protein uL16 family.
   
 
 0.550
ABN58269.1
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: mhu:Mhun_2549 thermosome.
  
  
 0.539
ABN57911.1
KEGG: mhu:Mhun_2617 hypothetical protein.
       0.532
ABN56813.1
PFAM: heat shock protein DnaJ domain protein; KEGG: mhu:Mhun_0257 heat shock protein DnaJ-like.
  
 
 0.516
ABN57240.1
PFAM: heat shock protein DnaJ domain protein; KEGG: syd:Syncc9605_0024 heat shock protein DnaJ.
  
 
 0.516
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.514
ABN56268.1
KEGG: mhu:Mhun_0779 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp.
   
 
 0.493
Your Current Organism:
Methanoculleus marisnigri
NCBI taxonomy Id: 368407
Other names: M. marisnigri JR1, Methanoculleus marisnigri JR1, Methanoculleus marisnigri str. JR1, Methanoculleus marisnigri strain JR1
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