Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABN57924.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (548 aa)    
Predicted Functional Partners:
tmk
PFAM: thymidylate kinase; KEGG: mhu:Mhun_2629 thymidylate kinase.
  
 
 0.960
ABN56254.1
KEGG: mhu:Mhun_2810 glutaredoxin-like protein.
  
 0.939
ABN58376.1
PFAM: glutaredoxin; KEGG: mma:MM3271 glutaredoxin.
  
 0.939
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
  
 
 0.937
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.925
adkA
KEGG: mhu:Mhun_2229 adenylate kinase; Belongs to the archaeal adenylate kinase family.
  
  
  0.914
ABN57829.1
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
   
 
  0.908
cmk
TIGRFAM: cytidylate kinase, putative; KEGG: mhu:Mhun_2227 cytidylate kinase, putative.
    
  0.904
ABN55969.1
Nucleotide kinase-like protein; KEGG: mhu:Mhun_2012 ATPase.
     
  0.900
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.871
Your Current Organism:
Methanoculleus marisnigri
NCBI taxonomy Id: 368407
Other names: M. marisnigri JR1, Methanoculleus marisnigri JR1, Methanoculleus marisnigri str. JR1, Methanoculleus marisnigri strain JR1
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