Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABN58075.1PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: mhu:Mhun_2447 methionine synthase, vitamin-B12 independent. (300 aa)    
Predicted Functional Partners:
ABN56579.1
Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.
  
 
 0.981
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.922
ABN56771.1
PFAM: S-adenosylmethionine synthetase (MAT); KEGG: mhu:Mhun_0923 methionine adenosyltransferase.
  
  
 0.920
ABN57446.1
PFAM: CBS domain containing protein; protein of unknown function DUF39; KEGG: mhu:Mhun_0138 protein of unknown function DUF39.
     
 0.901
ABN57447.1
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mhu:Mhun_0137 4Fe-4S ferredoxin, iron-sulfur binding.
     
  0.900
ABN56904.1
PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: mhu:Mhun_2292 homoserine dehydrogenase.
  
 
 0.895
ABN56385.1
TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mba:Mbar_A2422 cysteine synthase.
  
 
 0.892
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
 
   
 0.881
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
     
 0.849
ABN57166.1
PFAM: GHMP kinase; KEGG: mhu:Mhun_0831 GHMP kinase.
  
    0.798
Your Current Organism:
Methanoculleus marisnigri
NCBI taxonomy Id: 368407
Other names: M. marisnigri JR1, Methanoculleus marisnigri JR1, Methanoculleus marisnigri str. JR1, Methanoculleus marisnigri strain JR1
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