| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Tpen_0093 | Tpen_0142 | Tpen_0093 | Tpen_0142 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | 0.931 |
| Tpen_0093 | Tpen_0438 | Tpen_0093 | Tpen_0438 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | KEGG: pai:PAE2951 hypothetical protein. | 0.900 |
| Tpen_0093 | Tpen_0444 | Tpen_0093 | Tpen_0444 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.900 |
| Tpen_0093 | adk | Tpen_0093 | Tpen_0010 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.910 |
| Tpen_0093 | adk-2 | Tpen_0093 | Tpen_0167 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.910 |
| Tpen_0093 | surE | Tpen_0093 | Tpen_1004 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | 5'-nucleotidase / exopolyphosphatase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.931 |
| Tpen_0142 | Tpen_0093 | Tpen_0142 | Tpen_0093 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | 0.931 |
| Tpen_0142 | Tpen_0438 | Tpen_0142 | Tpen_0438 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | KEGG: pai:PAE2951 hypothetical protein. | 0.900 |
| Tpen_0142 | Tpen_0444 | Tpen_0142 | Tpen_0444 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.900 |
| Tpen_0142 | adk | Tpen_0142 | Tpen_0010 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.918 |
| Tpen_0142 | adk-2 | Tpen_0142 | Tpen_0167 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.918 |
| Tpen_0142 | surE | Tpen_0142 | Tpen_1004 | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | 5'-nucleotidase / exopolyphosphatase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
| Tpen_0438 | Tpen_0093 | Tpen_0438 | Tpen_0093 | KEGG: pai:PAE2951 hypothetical protein. | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | 0.900 |
| Tpen_0438 | Tpen_0142 | Tpen_0438 | Tpen_0142 | KEGG: pai:PAE2951 hypothetical protein. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; KEGG: tma:TM1662 acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE. | 0.900 |
| Tpen_0438 | Tpen_0444 | Tpen_0438 | Tpen_0444 | KEGG: pai:PAE2951 hypothetical protein. | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.900 |
| Tpen_0438 | Tpen_1005 | Tpen_0438 | Tpen_1005 | KEGG: pai:PAE2951 hypothetical protein. | Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. | 0.900 |
| Tpen_0438 | adk | Tpen_0438 | Tpen_0010 | KEGG: pai:PAE2951 hypothetical protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.900 |
| Tpen_0438 | adk-2 | Tpen_0438 | Tpen_0167 | KEGG: pai:PAE2951 hypothetical protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.900 |
| Tpen_0438 | surE | Tpen_0438 | Tpen_1004 | KEGG: pai:PAE2951 hypothetical protein. | 5'-nucleotidase / exopolyphosphatase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| Tpen_0438 | thiL | Tpen_0438 | Tpen_0476 | KEGG: pai:PAE2951 hypothetical protein. | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |