STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tpen_0383PFAM: phosphoribosyltransferase; KEGG: ape:APE2071 hypoxanthine phosphoribosyltransferase. (186 aa)    
Predicted Functional Partners:
Tpen_0386
KEGG: mca:MCA1716 ribose-phosphate pyrophosphokinase family protein; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family.
  
  
 0.649
Tpen_0384
Ribose 1,5-bisphosphate isomerase; KEGG: tko:TK0185 translation initiation factor eIF-2B, delta subunit; TIGRFAM: putative translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized proteins; PFAM: initiation factor 2B related; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
    0.629
Tpen_0385
PFAM: initiation factor 2B related; KEGG: pho:PH0208 translation initiation factor eIF-2B delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
    0.629
Tpen_0382
Hypothetical protein.
       0.476
Tpen_0391
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Nucleolar GTP-binding 1; KEGG: pai:PAE3626 hypothetical protein.
  
    0.439
rtcA
RNA-3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
    0.410
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.