STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (322 aa)    
Predicted Functional Partners:
Tpen_0927
TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; KEGG: afu:AF1736 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family.
 0.995
Tpen_0764
TIGRFAM: putative hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal domain; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; KEGG: pfu:PF0972 3-oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family.
 
  
 0.736
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.675
trpB
Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.610
Tpen_0606
Geranyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: pai:PAE1013 dimethylallyltranstransferase / geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
  
 0.560
Tpen_0765
PFAM: Thiolase; KEGG: pab:PAB0907 3-ketoacyl-CoA thiolase.
  
 
 0.522
Tpen_0892
Hypothetical protein.
       0.515
Tpen_1166
KEGG: pai:PAE1503 hypothetical protein.
  
 
 0.503
Tpen_0893
TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: pai:PAE2867 acetyl-coenzyme A synthetase.
  
  
 0.490
Tpen_1114
Galactokinase; PFAM: GHMP kinase; GHMP kinase, C terminal domain protein; KEGG: pai:PAE1185 galactokinase.
  
   
0.489
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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