STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egsA3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (347 aa)    
Predicted Functional Partners:
Tpen_1127
PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase; KEGG: dvu:DVU2673 anaerobic glycerol-3-phosphate dehydrogenase, subunit A, truncation.
 
  
 0.947
Tpen_0633
Geranylgeranylglyceryl diphosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
     
 0.935
Tpen_1375
PFAM: FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: afu:AF1328 glycerol-3-phosphate dehydrogenase.
    
  0.903
Tpen_1465
PFAM: class II aldolase/adducin family protein; KEGG: tvo:TVN1450 fuculose-1-phosphate aldolase.
  
  
 0.668
Tpen_1232
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: ape:APE2277 nitrilase.
       0.602
Tpen_0903
Hypothetical protein.
  
  
 0.534
Tpen_1006
PFAM: iron-containing alcohol dehydrogenase; KEGG: tma:TM0920 alcohol dehydrogenase, iron-containing.
  
  
0.534
gyaR
Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: pab:PAB2374 glycerate dehydrogenase.
  
  
 0.488
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
   
 0.453
nadK
NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
   
 0.449
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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