STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (327 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.999
Tpen_1602
TIGRFAM: CRISPR-associated protein Cas4; KEGG: sso:SSO0001 hypothetical protein.
   
 
 0.841
Tpen_1354
CRISPR-associated helicase Cas3; KEGG: pfu:PF0640 ATP-dependent RNA helicase, putative; TIGRFAM: CRISPR-associated helicase Cas3; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like.
 
  
 0.773
Tpen_1320
TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; PFAM: protein of unknown function DUF324; KEGG: sso:SSO1726 hypothetical protein.
 
   
 0.646
Tpen_1364
TIGRFAM: CRISPR-associated RAMP protein, Csm3 family; PFAM: protein of unknown function DUF324; KEGG: pai:PAE0114 hypothetical protein.
 
     0.513
Tpen_0717
PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: nha:Nham_1304 oxidoreductase-like.
  
 
 0.511
Tpen_1013
Oxidoreductase domain protein; PFAM: Semialdehyde dehydrogenase, NAD - binding; oxidoreductase domain protein; Oxidoreductase, C-terminal domain; homoserine dehydrogenase, NAD-binding; KEGG: cpf:CPF_0085 myo-inositol 2-dehydrogenase.
  
 
 0.511
Tpen_1096
Oxidoreductase domain protein; PFAM: Semialdehyde dehydrogenase, NAD - binding; oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: sth:STH2697 putative oxidoreductase.
  
 
 0.511
Tpen_1317
TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; PFAM: protein of unknown function DUF324; KEGG: sso:SSO1990 hypothetical protein.
 
     0.469
Tpen_0958
SMART: AAA ATPase; KEGG: afu:AF1960 DNA helicase, putative.
     
 0.453
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.