node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKC46347.1 | SKC88016.1 | SAMN02194393_00916 | SAMN02194393_04803 | ATP-dependent DNA helicase, RecQ-like. | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | 0.779 |
SKC46347.1 | SKC88866.1 | SAMN02194393_00916 | SAMN02194393_04930 | ATP-dependent DNA helicase, RecQ-like. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.912 |
SKC46347.1 | mutL | SAMN02194393_00916 | SAMN02194393_02696 | ATP-dependent DNA helicase, RecQ-like. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.921 |
SKC46347.1 | polA | SAMN02194393_00916 | SAMN02194393_01911 | ATP-dependent DNA helicase, RecQ-like. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.994 |
SKC46347.1 | recA | SAMN02194393_00916 | SAMN02194393_02796 | ATP-dependent DNA helicase, RecQ-like. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.974 |
SKC88001.1 | SKC88016.1 | SAMN02194393_04802 | SAMN02194393_04803 | MazG nucleotide pyrophosphohydrolase domain-containing protein. | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | 0.546 |
SKC88016.1 | SKC46347.1 | SAMN02194393_04803 | SAMN02194393_00916 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | ATP-dependent DNA helicase, RecQ-like. | 0.779 |
SKC88016.1 | SKC88001.1 | SAMN02194393_04803 | SAMN02194393_04802 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | MazG nucleotide pyrophosphohydrolase domain-containing protein. | 0.546 |
SKC88016.1 | SKC88866.1 | SAMN02194393_04803 | SAMN02194393_04930 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.956 |
SKC88016.1 | ligA | SAMN02194393_04803 | SAMN02194393_04463 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.528 |
SKC88016.1 | metN | SAMN02194393_04803 | SAMN02194393_04385 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.549 |
SKC88016.1 | mutL | SAMN02194393_04803 | SAMN02194393_02696 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.988 |
SKC88016.1 | mutS2 | SAMN02194393_04803 | SAMN02194393_00837 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. | 0.632 |
SKC88016.1 | polA | SAMN02194393_04803 | SAMN02194393_01911 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.960 |
SKC88016.1 | proA | SAMN02194393_04803 | SAMN02194393_04792 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.482 |
SKC88016.1 | recA | SAMN02194393_04803 | SAMN02194393_02796 | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.574 |
SKC88866.1 | SKC46347.1 | SAMN02194393_04930 | SAMN02194393_00916 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase, RecQ-like. | 0.912 |
SKC88866.1 | SKC88016.1 | SAMN02194393_04930 | SAMN02194393_04803 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Mismatch repair ATPase (MutS family); Belongs to the DNA mismatch repair MutS family. | 0.956 |
SKC88866.1 | ligA | SAMN02194393_04930 | SAMN02194393_04463 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.808 |
SKC88866.1 | mutL | SAMN02194393_04930 | SAMN02194393_02696 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.980 |