STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A9PA83_POPTRHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)    
Predicted Functional Partners:
A0A2K1Y254
Uncharacterized protein.
    
 0.990
A0A2K1Z3A1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
    
 0.975
A0A2K1Z5I7
RPOLD domain-containing protein.
    
 0.968
A0A2K2C685
Plus3 domain-containing protein.
    
 0.968
A0A3N7FQY3
Plus3 domain-containing protein.
    
 0.968
A9PCB4_POPTR
RNA_pol_L_2 domain-containing protein.
    
 0.960
B9GUG6_POPTR
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
    
 0.956
B9H794_POPTR
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
    
 0.956
B9HUV8_POPTR
Histone H2B; Belongs to the histone H2B family.
  
 0.951
B9H5K4_POPTR
RPOL4c domain-containing protein.
    
  0.950
Your Current Organism:
Populus trichocarpa
NCBI taxonomy Id: 3694
Other names: P. trichocarpa, Populus balsamifera subsp. trichocarpa, Populus balsamifera subsp. trichocarpa (Torr. & A.Gray) Brayshaw, Populus trichocarpa Torr. & A.Gray, black cottonwood, western balsam poplar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.