ABP55426.1 protein (Salinispora tropica) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ABP55426.1

PFAM: regulatory protein, TetR. (210 aa)

Predicted Functional Partners:

ABP55425.1

0.779

ABP56096.1

0.515

ABP55427.1

0.494

ABP53887.1

0.490

ABP55810.1

0.443

ABP54625.1

0.427

ABP54115.1

0.404

Your Current Organism:

Salinispora tropica

NCBI taxonomy Id: 369723
Other names: S. tropica CNB-440, Salinispora sp. CNB-440, Salinispora tropica ATCC BAA-916, Salinispora tropica CNB-440, Salinispora tropica str. CNB-440, Salinispora tropica strain CNB-440

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABP53887.1	ABP55426.1	Strop_1420	Strop_2988	PFAM: MMPL domain protein.	PFAM: regulatory protein, TetR.	0.490
ABP54115.1	ABP55426.1	Strop_1650	Strop_2988	PFAM: regulatory protein, LuxR.	PFAM: regulatory protein, TetR.	0.404
ABP54625.1	ABP55426.1	Strop_2174	Strop_2988	Hypothetical protein.	PFAM: regulatory protein, TetR.	0.427
ABP55425.1	ABP55426.1	Strop_2987	Strop_2988	PFAM: MMPL domain protein.	PFAM: regulatory protein, TetR.	0.779
ABP55426.1	ABP53887.1	Strop_2988	Strop_1420	PFAM: regulatory protein, TetR.	PFAM: MMPL domain protein.	0.490
ABP55426.1	ABP54115.1	Strop_2988	Strop_1650	PFAM: regulatory protein, TetR.	PFAM: regulatory protein, LuxR.	0.404
ABP55426.1	ABP54625.1	Strop_2988	Strop_2174	PFAM: regulatory protein, TetR.	Hypothetical protein.	0.427
ABP55426.1	ABP55425.1	Strop_2988	Strop_2987	PFAM: regulatory protein, TetR.	PFAM: MMPL domain protein.	0.779
ABP55426.1	ABP55427.1	Strop_2988	Strop_2989	PFAM: regulatory protein, TetR.	Hypothetical protein.	0.494
ABP55426.1	ABP55810.1	Strop_2988	Strop_3377	PFAM: regulatory protein, TetR.	Hypothetical protein.	0.443
ABP55426.1	ABP56096.1	Strop_2988	Strop_3665	PFAM: regulatory protein, TetR.	PFAM: MMPL domain protein.	0.515
ABP55427.1	ABP55426.1	Strop_2989	Strop_2988	Hypothetical protein.	PFAM: regulatory protein, TetR.	0.494
ABP55810.1	ABP55426.1	Strop_3377	Strop_2988	Hypothetical protein.	PFAM: regulatory protein, TetR.	0.443
ABP56096.1	ABP55426.1	Strop_3665	Strop_2988	PFAM: MMPL domain protein.	PFAM: regulatory protein, TetR.	0.515

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

2.99e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 56

2.23

7.35

1.96e-18

GO:0000470

Maturation of LSU-rRNA

7 of 27

2.39

5.94

3.87e-13

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 20

2.37

4.07

7.49e-09

GO:0006364

rRNA processing

10 of 182

1.71

4.06

3.40e-14

GO:0042254

Ribosome biogenesis

11 of 246

1.63

3.81

2.93e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

6 of 484

1.07

0.77

0.0058

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

6 of 25

2.36

4.8

1.50e-10

GO:0030684

Preribosome

7 of 72

1.96

4.06

1.50e-10

GO:0005730

Nucleolus

8 of 210

1.56

2.74

1.34e-09

GO:0005634

Nucleus

9 of 1888

0.65

0.54

0.00060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5304

Ribosomal large subunit biogenesis, and CBF/Mak21 family

11 of 41

2.4

9.76

2.48e-23

CL:5307

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

9 of 27

2.5

8.67

2.96e-19

CL:5316

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Ribosomal protein L1-like

5 of 7

2.83

5.57

3.31e-11

CL:5309

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

6 of 22

2.41

5.39

9.62e-12

CL:5368

CBF/Mak21 family, and RNA helicase, DEAD-box type, Q motif

2 of 5

2.58

1.51

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

5 of 105

1.65

1.83

4.93e-05

MAP-8868773

rRNA processing in the nucleus and cytosol

5 of 107

1.64

1.82

4.93e-05

MAP-72312

rRNA processing

5 of 111

1.63

1.8

4.93e-05

MAP-8953854

Metabolism of RNA

5 of 460

1.01

0.64

0.0150

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

6 of 106

1.73

2.61

2.78e-07

GOCC:0031981

Nuclear lumen

9 of 473

1.25

1.75

4.30e-08

GOCC:0030688

Preribosome, small subunit precursor

2 of 11

2.23

1.1

0.0091

GOCC:0030684

Preribosome

3 of 64

1.65

1.09

0.0053

GOCC:0030687

Preribosome, large subunit precursor

2 of 21

1.95

0.92

0.0180

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

2 of 14

2.13

0.84

0.0274

KW-0690

Ribosome biogenesis

2 of 17

2.05

0.83

0.0274

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