rskr protein (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Score

rskr

Ribosomal protein S6 kinase related b. (255 aa)

Predicted Functional Partners:

pdpk1

0.705

LOC108251011

0.479

ELAVL2

0.479

LOC108234905

0.479

elavl3

0.479

elavl4

0.479

ENSKMAP00000024068

0.472

ENSKMAP00000025284

0.472

ENSKMAP00000014863

0.467

LOC108249566

0.467

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELAVL2	rskr	ENSKMAP00000008390	ENSKMAP00000000207	ELAV-like protein; Belongs to the RRM elav family.	Ribosomal protein S6 kinase related b.	0.479
ENSKMAP00000014863	rskr	ENSKMAP00000014863	ENSKMAP00000000207	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Ribosomal protein S6 kinase related b.	0.467
ENSKMAP00000024068	rskr	ENSKMAP00000024068	ENSKMAP00000000207	Ig-like domain-containing protein.	Ribosomal protein S6 kinase related b.	0.472
ENSKMAP00000025284	rskr	ENSKMAP00000025284	ENSKMAP00000000207	Uncharacterized protein.	Ribosomal protein S6 kinase related b.	0.472
LOC108234905	rskr	ENSKMAP00000018899	ENSKMAP00000000207	ELAV like RNA binding protein 1a.	Ribosomal protein S6 kinase related b.	0.479
LOC108249566	rskr	ENSKMAP00000024356	ENSKMAP00000000207	Ubiquitin-conjugating enzyme E2 variant 1.	Ribosomal protein S6 kinase related b.	0.467
LOC108251011	rskr	ENSKMAP00000008338	ENSKMAP00000000207	ELAV-like protein; Belongs to the RRM elav family.	Ribosomal protein S6 kinase related b.	0.479
elavl3	rskr	ENSKMAP00000023482	ENSKMAP00000000207	ELAV-like protein; Belongs to the RRM elav family.	Ribosomal protein S6 kinase related b.	0.479
elavl4	rskr	ENSKMAP00000030152	ENSKMAP00000000207	ELAV-like protein; Belongs to the RRM elav family.	Ribosomal protein S6 kinase related b.	0.479
pdpk1	rskr	ENSKMAP00000016374	ENSKMAP00000000207	3-phosphoinositide dependent protein kinase 1b.	Ribosomal protein S6 kinase related b.	0.705
rskr	ELAVL2	ENSKMAP00000000207	ENSKMAP00000008390	Ribosomal protein S6 kinase related b.	ELAV-like protein; Belongs to the RRM elav family.	0.479
rskr	ENSKMAP00000014863	ENSKMAP00000000207	ENSKMAP00000014863	Ribosomal protein S6 kinase related b.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.467
rskr	ENSKMAP00000024068	ENSKMAP00000000207	ENSKMAP00000024068	Ribosomal protein S6 kinase related b.	Ig-like domain-containing protein.	0.472
rskr	ENSKMAP00000025284	ENSKMAP00000000207	ENSKMAP00000025284	Ribosomal protein S6 kinase related b.	Uncharacterized protein.	0.472
rskr	LOC108234905	ENSKMAP00000000207	ENSKMAP00000018899	Ribosomal protein S6 kinase related b.	ELAV like RNA binding protein 1a.	0.479
rskr	LOC108249566	ENSKMAP00000000207	ENSKMAP00000024356	Ribosomal protein S6 kinase related b.	Ubiquitin-conjugating enzyme E2 variant 1.	0.467
rskr	LOC108251011	ENSKMAP00000000207	ENSKMAP00000008338	Ribosomal protein S6 kinase related b.	ELAV-like protein; Belongs to the RRM elav family.	0.479
rskr	elavl3	ENSKMAP00000000207	ENSKMAP00000023482	Ribosomal protein S6 kinase related b.	ELAV-like protein; Belongs to the RRM elav family.	0.479
rskr	elavl4	ENSKMAP00000000207	ENSKMAP00000030152	Ribosomal protein S6 kinase related b.	ELAV-like protein; Belongs to the RRM elav family.	0.479
rskr	pdpk1	ENSKMAP00000000207	ENSKMAP00000016374	Ribosomal protein S6 kinase related b.	3-phosphoinositide dependent protein kinase 1b.	0.705

Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

0.0162

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002031

G protein-coupled receptor internalization

3 of 6

2.82

2.11

0.00014

GO:0050909

Sensory perception of taste

3 of 27

2.17

1.55

0.0011

GO:0007200

Phospholipase C-activating G protein-coupled receptor signaling pathway

3 of 36

2.04

1.39

0.0020

GO:0007606

Sensory perception of chemical stimulus

6 of 410

1.29

1.25

0.00024

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 5

2.73

1.22

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

6 of 166

1.68

2.24

2.92e-06

GO:0031690

Adrenergic receptor binding

2 of 9

2.47

0.88

0.0251

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 12

2.34

0.87

0.0254

GO:0071855

Neuropeptide receptor binding

2 of 16

2.22

0.79

0.0355

GO:0003924

GTPase activity

4 of 214

1.39

0.78

0.0199

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 26

2.41

3.91

2.04e-08

GO:0042995

Cell projection

8 of 1389

0.88

0.81

0.00016

GO:0120025

Plasma membrane bounded cell projection

7 of 1332

0.84

0.67

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24323

Mixed, incl. Activation of GABAB receptors, and Amine ligand-binding receptors

5 of 53

2.1

2.86

1.18e-06

CL:24314

GPCR ligand binding, and G-protein mediated events

6 of 149

1.73

2.43

1.18e-06

CL:24328

Activation of GABAB receptors, and Dopamine receptor family

3 of 16

2.4

2.08

0.00012

CL:24346

Adenylate cyclase activating pathway, and G-protein alpha subunit, group S

2 of 7

2.58

1.25

0.0053

CL:24684

Mixed, incl. Protein kinase inhibitor, and Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

2 of 13

2.31

1.0

0.0141

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05032

Morphine addiction

8 of 69

2.19

5.9

2.31e-14

map04728

Dopaminergic synapse

8 of 103

2.01

5.03

2.40e-13

map04926

Relaxin signaling pathway

7 of 111

1.92

4.06

6.93e-11

map04724

Glutamatergic synapse

6 of 94

1.93

3.59

2.75e-09

map04062

Chemokine signaling pathway

7 of 154

1.78

3.45

4.76e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

5 of 28

2.37

4.11

6.48e-09

MAP-418555

G alpha (s) signalling events

7 of 109

1.93

3.89

2.93e-10

MAP-111885

Opioid Signalling

6 of 71

2.05

3.79

3.28e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

4 of 29

2.26

2.92

1.66e-06

MAP-432040

Vasopressin regulates renal water homeostasis via Aquaporins

4 of 31

2.23

2.88

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 8

2.82

3.7

1.39e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.58

0.82

0.0326

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017864

Arrestin, conserved site

2 of 2

3.12

1.03

0.0142

IPR014753

Arrestin, N-terminal

2 of 2

3.12

1.03

0.0142

IPR000698

Arrestin

2 of 2

3.12

1.03

0.0142

IPR000367

G-protein alpha subunit, group S

2 of 2

3.12

1.03

0.0142

IPR011022

Arrestin C-terminal-like domain

2 of 6

2.65

1.02

0.0142

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

2 of 11

2.38

0.86

0.0262

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