znf367 protein (Kryptolebias marmoratus) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

znf367

Zinc finger protein 367. (310 aa)

Predicted Functional Partners:

mrps27

0.755

fbxl17

0.686

ubox5

0.680

thnsl2

0.679

ddrgk1

0.679

ptpra

0.660

ap5s1

0.630

sgf29

0.622

gstcd

0.583

LOC108251021

0.582

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108251021	znf367	ENSKMAP00000008588	ENSKMAP00000000237	Uncharacterized protein.	Zinc finger protein 367.	0.582
ap5s1	znf367	ENSKMAP00000011160	ENSKMAP00000000237	Adaptor related protein complex 5 subunit sigma 1.	Zinc finger protein 367.	0.630
ddrgk1	ptpra	ENSKMAP00000016781	ENSKMAP00000025474	Uncharacterized protein.	Receptor-type tyrosine-protein phosphatase alpha.	0.661
ddrgk1	thnsl2	ENSKMAP00000016781	ENSKMAP00000003621	Uncharacterized protein.	Threonine synthase-like 2.	0.679
ddrgk1	ubox5	ENSKMAP00000016781	ENSKMAP00000000282	Uncharacterized protein.	U-box domain containing 5.	0.661
ddrgk1	znf367	ENSKMAP00000016781	ENSKMAP00000000237	Uncharacterized protein.	Zinc finger protein 367.	0.679
fbxl17	mrps27	ENSKMAP00000030116	ENSKMAP00000000573	F-box and leucine-rich repeat protein 17.	Mitochondrial ribosomal protein S27.	0.662
fbxl17	ubox5	ENSKMAP00000030116	ENSKMAP00000000282	F-box and leucine-rich repeat protein 17.	U-box domain containing 5.	0.660
fbxl17	znf367	ENSKMAP00000030116	ENSKMAP00000000237	F-box and leucine-rich repeat protein 17.	Zinc finger protein 367.	0.686
gstcd	sgf29	ENSKMAP00000001710	ENSKMAP00000005754	Glutathione S-transferase, C-terminal domain containing.	SAGA complex associated factor 29.	0.408
gstcd	znf367	ENSKMAP00000001710	ENSKMAP00000000237	Glutathione S-transferase, C-terminal domain containing.	Zinc finger protein 367.	0.583
mrps27	fbxl17	ENSKMAP00000000573	ENSKMAP00000030116	Mitochondrial ribosomal protein S27.	F-box and leucine-rich repeat protein 17.	0.662
mrps27	ubox5	ENSKMAP00000000573	ENSKMAP00000000282	Mitochondrial ribosomal protein S27.	U-box domain containing 5.	0.635
mrps27	znf367	ENSKMAP00000000573	ENSKMAP00000000237	Mitochondrial ribosomal protein S27.	Zinc finger protein 367.	0.755
ptpra	ddrgk1	ENSKMAP00000025474	ENSKMAP00000016781	Receptor-type tyrosine-protein phosphatase alpha.	Uncharacterized protein.	0.661
ptpra	thnsl2	ENSKMAP00000025474	ENSKMAP00000003621	Receptor-type tyrosine-protein phosphatase alpha.	Threonine synthase-like 2.	0.661
ptpra	ubox5	ENSKMAP00000025474	ENSKMAP00000000282	Receptor-type tyrosine-protein phosphatase alpha.	U-box domain containing 5.	0.662
ptpra	znf367	ENSKMAP00000025474	ENSKMAP00000000237	Receptor-type tyrosine-protein phosphatase alpha.	Zinc finger protein 367.	0.660
sgf29	gstcd	ENSKMAP00000005754	ENSKMAP00000001710	SAGA complex associated factor 29.	Glutathione S-transferase, C-terminal domain containing.	0.408
sgf29	znf367	ENSKMAP00000005754	ENSKMAP00000000237	SAGA complex associated factor 29.	Zinc finger protein 367.	0.622

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

0.0162

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002031

G protein-coupled receptor internalization

3 of 6

2.82

2.11

0.00014

GO:0050909

Sensory perception of taste

3 of 27

2.17

1.55

0.0011

GO:0007200

Phospholipase C-activating G protein-coupled receptor signaling pathway

3 of 36

2.04

1.39

0.0020

GO:0007606

Sensory perception of chemical stimulus

6 of 410

1.29

1.25

0.00024

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 5

2.73

1.22

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

6 of 166

1.68

2.24

2.92e-06

GO:0031690

Adrenergic receptor binding

2 of 9

2.47

0.88

0.0251

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 12

2.34

0.87

0.0254

GO:0071855

Neuropeptide receptor binding

2 of 16

2.22

0.79

0.0355

GO:0003924

GTPase activity

4 of 214

1.39

0.78

0.0199

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 26

2.41

3.91

2.04e-08

GO:0042995

Cell projection

8 of 1389

0.88

0.81

0.00016

GO:0120025

Plasma membrane bounded cell projection

7 of 1332

0.84

0.67

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24323

Mixed, incl. Activation of GABAB receptors, and Amine ligand-binding receptors

5 of 53

2.1

2.86

1.18e-06

CL:24314

GPCR ligand binding, and G-protein mediated events

6 of 149

1.73

2.43

1.18e-06

CL:24328

Activation of GABAB receptors, and Dopamine receptor family

3 of 16

2.4

2.08

0.00012

CL:24346

Adenylate cyclase activating pathway, and G-protein alpha subunit, group S

2 of 7

2.58

1.25

0.0053

CL:24684

Mixed, incl. Protein kinase inhibitor, and Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

2 of 13

2.31

1.0

0.0141

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05032

Morphine addiction

8 of 69

2.19

5.9

2.31e-14

map04728

Dopaminergic synapse

8 of 103

2.01

5.03

2.40e-13

map04926

Relaxin signaling pathway

7 of 111

1.92

4.06

6.93e-11

map04724

Glutamatergic synapse

6 of 94

1.93

3.59

2.75e-09

map04062

Chemokine signaling pathway

7 of 154

1.78

3.45

4.76e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

5 of 28

2.37

4.11

6.48e-09

MAP-418555

G alpha (s) signalling events

7 of 109

1.93

3.89

2.93e-10

MAP-111885

Opioid Signalling

6 of 71

2.05

3.79

3.28e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

4 of 29

2.26

2.92

1.66e-06

MAP-432040

Vasopressin regulates renal water homeostasis via Aquaporins

4 of 31

2.23

2.88

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 8

2.82

3.7

1.39e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.58

0.82

0.0326

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017864

Arrestin, conserved site

2 of 2

3.12

1.03

0.0142

IPR014753

Arrestin, N-terminal

2 of 2

3.12

1.03

0.0142

IPR000698

Arrestin

2 of 2

3.12

1.03

0.0142

IPR000367

G-protein alpha subunit, group S

2 of 2

3.12

1.03

0.0142

IPR011022

Arrestin C-terminal-like domain

2 of 6

2.65

1.02

0.0142

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

2 of 11

2.38

0.86

0.0262

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