LOC108250227 protein (Kryptolebias marmoratus)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC108250227

Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)

Predicted Functional Partners:

fzd4

0.863

Fzd2

0.854

FZD7

0.844

ENSKMAP00000021756

0.832

sfrp2

0.821

LOC108248723

0.813

sfrp5

0.807

fzd9

0.800

Fzd10

0.800

LOC108228356

0.798

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000021756	LOC108248723	ENSKMAP00000021756	ENSKMAP00000010993	Frizzled class receptor 1.	Secreted frizzled-related protein 1a.	0.650
ENSKMAP00000021756	LOC108250227	ENSKMAP00000021756	ENSKMAP00000000460	Frizzled class receptor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.832
ENSKMAP00000021756	sfrp2	ENSKMAP00000021756	ENSKMAP00000008832	Frizzled class receptor 1.	Secreted frizzled-related protein 2.	0.650
ENSKMAP00000021756	sfrp5	ENSKMAP00000021756	ENSKMAP00000028896	Frizzled class receptor 1.	Secreted frizzled-related protein 5.	0.650
FZD7	LOC108248723	ENSKMAP00000001744	ENSKMAP00000010993	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.679
FZD7	LOC108250227	ENSKMAP00000001744	ENSKMAP00000000460	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.844
FZD7	sfrp2	ENSKMAP00000001744	ENSKMAP00000008832	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.681
FZD7	sfrp5	ENSKMAP00000001744	ENSKMAP00000028896	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.679
Fzd10	LOC108248723	ENSKMAP00000027488	ENSKMAP00000010993	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.671
Fzd10	LOC108250227	ENSKMAP00000027488	ENSKMAP00000000460	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.800
Fzd10	sfrp2	ENSKMAP00000027488	ENSKMAP00000008832	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.650
Fzd10	sfrp5	ENSKMAP00000027488	ENSKMAP00000028896	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.671
Fzd2	LOC108248723	ENSKMAP00000026394	ENSKMAP00000010993	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.711
Fzd2	LOC108250227	ENSKMAP00000026394	ENSKMAP00000000460	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.854
Fzd2	sfrp2	ENSKMAP00000026394	ENSKMAP00000008832	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.681
Fzd2	sfrp5	ENSKMAP00000026394	ENSKMAP00000028896	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.716
LOC108228356	LOC108248723	ENSKMAP00000019246	ENSKMAP00000010993	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1a.	0.650
LOC108228356	LOC108250227	ENSKMAP00000019246	ENSKMAP00000000460	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.798
LOC108228356	sfrp2	ENSKMAP00000019246	ENSKMAP00000008832	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.650
LOC108228356	sfrp5	ENSKMAP00000019246	ENSKMAP00000028896	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.650

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

0.0162

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002031

G protein-coupled receptor internalization

3 of 6

2.82

2.11

0.00014

GO:0050909

Sensory perception of taste

3 of 27

2.17

1.55

0.0011

GO:0007200

Phospholipase C-activating G protein-coupled receptor signaling pathway

3 of 36

2.04

1.39

0.0020

GO:0007606

Sensory perception of chemical stimulus

6 of 410

1.29

1.25

0.00024

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 5

2.73

1.22

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

6 of 166

1.68

2.24

2.92e-06

GO:0031690

Adrenergic receptor binding

2 of 9

2.47

0.88

0.0251

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 12

2.34

0.87

0.0254

GO:0071855

Neuropeptide receptor binding

2 of 16

2.22

0.79

0.0355

GO:0003924

GTPase activity

4 of 214

1.39

0.78

0.0199

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 26

2.41

3.91

2.04e-08

GO:0042995

Cell projection

8 of 1389

0.88

0.81

0.00016

GO:0120025

Plasma membrane bounded cell projection

7 of 1332

0.84

0.67

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24323

Mixed, incl. Activation of GABAB receptors, and Amine ligand-binding receptors

5 of 53

2.1

2.86

1.18e-06

CL:24314

GPCR ligand binding, and G-protein mediated events

6 of 149

1.73

2.43

1.18e-06

CL:24328

Activation of GABAB receptors, and Dopamine receptor family

3 of 16

2.4

2.08

0.00012

CL:24346

Adenylate cyclase activating pathway, and G-protein alpha subunit, group S

2 of 7

2.58

1.25

0.0053

CL:24684

Mixed, incl. Protein kinase inhibitor, and Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

2 of 13

2.31

1.0

0.0141

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05032

Morphine addiction

8 of 69

2.19

5.9

2.31e-14

map04728

Dopaminergic synapse

8 of 103

2.01

5.03

2.40e-13

map04926

Relaxin signaling pathway

7 of 111

1.92

4.06

6.93e-11

map04724

Glutamatergic synapse

6 of 94

1.93

3.59

2.75e-09

map04062

Chemokine signaling pathway

7 of 154

1.78

3.45

4.76e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

5 of 28

2.37

4.11

6.48e-09

MAP-418555

G alpha (s) signalling events

7 of 109

1.93

3.89

2.93e-10

MAP-111885

Opioid Signalling

6 of 71

2.05

3.79

3.28e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

4 of 29

2.26

2.92

1.66e-06

MAP-432040

Vasopressin regulates renal water homeostasis via Aquaporins

4 of 31

2.23

2.88

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 8

2.82

3.7

1.39e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.58

0.82

0.0326

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017864

Arrestin, conserved site

2 of 2

3.12

1.03

0.0142

IPR014753

Arrestin, N-terminal

2 of 2

3.12

1.03

0.0142

IPR000698

Arrestin

2 of 2

3.12

1.03

0.0142

IPR000367

G-protein alpha subunit, group S

2 of 2

3.12

1.03

0.0142

IPR011022

Arrestin C-terminal-like domain

2 of 6

2.65

1.02

0.0142

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

2 of 11

2.38

0.86

0.0262

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