STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN2ACyclin dependent kinase inhibitor 2A. (124 aa)    
Predicted Functional Partners:
mdm2
MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.
   
 0.959
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.847
mdm4
MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.
   
 0.836
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.815
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.764
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
 0.764
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.764
LOC112450491
Cyclin-dependent kinase inhibitor 1A.
    
 0.709
mtap
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
   
 0.685
ccnd1
Cyclin D1; Belongs to the cyclin family.
    
 0.663
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.