LOC108233110 protein (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC108233110

Uncharacterized protein. (193 aa)

Predicted Functional Partners:

rock1

0.970

rock2

0.970

ARHGEF2

0.968

diaph2

0.958

arhgef12

0.957

arhgef1

0.957

ROCK2

0.957

LOC108230620

0.957

Arhgap5

0.956

arhgap35

0.956

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	LOC108233110	ENSKMAP00000011350	ENSKMAP00000003736	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Uncharacterized protein.	0.968
Arhgap5	LOC108233110	ENSKMAP00000007070	ENSKMAP00000003736	Rho GTPase activating protein 5.	Uncharacterized protein.	0.956
Arhgap5	arhgap35	ENSKMAP00000007070	ENSKMAP00000011104	Rho GTPase activating protein 5.	Uncharacterized protein.	0.902
LOC108230620	LOC108233110	ENSKMAP00000029981	ENSKMAP00000003736	Rho/rac guanine nucleotide exchange factor (GEF) 18b.	Uncharacterized protein.	0.957
LOC108233110	ARHGEF2	ENSKMAP00000003736	ENSKMAP00000011350	Uncharacterized protein.	Rho/rac guanine nucleotide exchange factor (GEF) 2.	0.968
LOC108233110	Arhgap5	ENSKMAP00000003736	ENSKMAP00000007070	Uncharacterized protein.	Rho GTPase activating protein 5.	0.956
LOC108233110	LOC108230620	ENSKMAP00000003736	ENSKMAP00000029981	Uncharacterized protein.	Rho/rac guanine nucleotide exchange factor (GEF) 18b.	0.957
LOC108233110	ROCK2	ENSKMAP00000003736	ENSKMAP00000022828	Uncharacterized protein.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.957
LOC108233110	arhgap35	ENSKMAP00000003736	ENSKMAP00000011104	Uncharacterized protein.	Uncharacterized protein.	0.956
LOC108233110	arhgef1	ENSKMAP00000003736	ENSKMAP00000014461	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 1b.	0.957
LOC108233110	arhgef12	ENSKMAP00000003736	ENSKMAP00000013301	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 12a.	0.957
LOC108233110	diaph2	ENSKMAP00000003736	ENSKMAP00000026973	Uncharacterized protein.	Diaphanous-related formin 2.	0.958
LOC108233110	rock1	ENSKMAP00000003736	ENSKMAP00000005001	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.970
LOC108233110	rock2	ENSKMAP00000003736	ENSKMAP00000012030	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.970
ROCK2	LOC108233110	ENSKMAP00000022828	ENSKMAP00000003736	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Uncharacterized protein.	0.957
ROCK2	arhgef1	ENSKMAP00000022828	ENSKMAP00000014461	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho guanine nucleotide exchange factor (GEF) 1b.	0.419
ROCK2	arhgef12	ENSKMAP00000022828	ENSKMAP00000013301	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho guanine nucleotide exchange factor (GEF) 12a.	0.419
ROCK2	diaph2	ENSKMAP00000022828	ENSKMAP00000026973	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Diaphanous-related formin 2.	0.446
ROCK2	rock1	ENSKMAP00000022828	ENSKMAP00000005001	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.902
ROCK2	rock2	ENSKMAP00000022828	ENSKMAP00000012030	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.901

page 1 of 3

Network Stats

number of nodes:

7

number of edges:

7

average node degree:

2

avg. local clustering coefficient:

0.867

expected number of edges:

6

PPI enrichment p-value:

0.399

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000271

Polysaccharide biosynthetic process

7 of 51

1.59

2.41

1.64e-07

GO:0045226

Extracellular polysaccharide biosynthetic process

2 of 7

1.91

0.76

0.0364

GO:1901576

Organic substance biosynthetic process

8 of 559

0.61

0.41

0.0139

GO:0044238

Primary metabolic process

11 of 1019

0.48

0.4

0.00097

GO:0071704

Organic substance metabolic process

11 of 1255

0.39

0.31

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2111

Mixed, incl. O-Antigen nucleotide sugar biosynthesis, and Bacterial sugar transferase

10 of 44

1.81

4.58

7.34e-15

CL:2112

O-Antigen nucleotide sugar biosynthesis, and Citrate lyase beta subunit-like

7 of 27

1.87

3.76

2.27e-10

CL:2113

Mixed, incl. Citrate lyase beta subunit-like, and UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase

5 of 14

2.0

3.12

1.44e-07

CL:2115

Mixed, incl. UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase, and UDP-N-acetylglucosamine 2-epimerase

4 of 6

2.28

3.02

1.07e-06

CL:2168

Carbohydrate transport, and Peptidyl-tyrosine modification

3 of 6

2.15

1.96

0.00015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00541

O-Antigen nucleotide sugar biosynthesis

5 of 31

1.66

2.09

7.65e-06

map00525

Acarbose and validamycin biosynthesis

2 of 6

1.97

0.92

0.0178

map00523

Polyketide sugar unit biosynthesis

2 of 8

1.85

0.9

0.0178

map00521

Streptomycin biosynthesis

2 of 11

1.71

0.88

0.0178

map00520

Amino sugar and nucleotide sugar metabolism

3 of 43

1.3

0.76

0.0178

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About