node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GADD45A | LOC108231213 | ENSKMAP00000005518 | ENSKMAP00000025778 | Growth arrest and DNA-damage-inducible, alpha, b. | Aurora kinase B; Belongs to the protein kinase superfamily. | 0.657 |
GADD45A | TP53 | ENSKMAP00000005518 | ENSKMAP00000018969 | Growth arrest and DNA-damage-inducible, alpha, b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.962 |
GADD45A | aurka | ENSKMAP00000005518 | ENSKMAP00000017471 | Growth arrest and DNA-damage-inducible, alpha, b. | Aurora kinase A; Belongs to the protein kinase superfamily. | 0.657 |
GADD45A | ccnb1 | ENSKMAP00000005518 | ENSKMAP00000011977 | Growth arrest and DNA-damage-inducible, alpha, b. | Cyclin B1; Belongs to the cyclin family. | 0.924 |
GADD45A | ccnb3 | ENSKMAP00000005518 | ENSKMAP00000016387 | Growth arrest and DNA-damage-inducible, alpha, b. | Cyclin B3; Belongs to the cyclin family. | 0.917 |
GADD45A | cdk1 | ENSKMAP00000005518 | ENSKMAP00000020171 | Growth arrest and DNA-damage-inducible, alpha, b. | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | 0.935 |
GADD45A | cntd2 | ENSKMAP00000005518 | ENSKMAP00000004779 | Growth arrest and DNA-damage-inducible, alpha, b. | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. | 0.924 |
GADD45A | gadd45gip1 | ENSKMAP00000005518 | ENSKMAP00000012387 | Growth arrest and DNA-damage-inducible, alpha, b. | Growth arrest and DNA-damage-inducible, gamma interacting protein 1. | 0.680 |
GADD45A | map3k4 | ENSKMAP00000005518 | ENSKMAP00000023468 | Growth arrest and DNA-damage-inducible, alpha, b. | Mitogen-activated protein kinase kinase kinase 4. | 0.973 |
GADD45A | pcna | ENSKMAP00000005518 | ENSKMAP00000003800 | Growth arrest and DNA-damage-inducible, alpha, b. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.989 |
LOC108231213 | GADD45A | ENSKMAP00000025778 | ENSKMAP00000005518 | Aurora kinase B; Belongs to the protein kinase superfamily. | Growth arrest and DNA-damage-inducible, alpha, b. | 0.657 |
LOC108231213 | TP53 | ENSKMAP00000025778 | ENSKMAP00000018969 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.830 |
LOC108231213 | ccnb1 | ENSKMAP00000025778 | ENSKMAP00000011977 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cyclin B1; Belongs to the cyclin family. | 0.702 |
LOC108231213 | ccnb3 | ENSKMAP00000025778 | ENSKMAP00000016387 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cyclin B3; Belongs to the cyclin family. | 0.659 |
LOC108231213 | cdk1 | ENSKMAP00000025778 | ENSKMAP00000020171 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | 0.744 |
LOC108231213 | cntd2 | ENSKMAP00000025778 | ENSKMAP00000004779 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. | 0.681 |
TP53 | GADD45A | ENSKMAP00000018969 | ENSKMAP00000005518 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Growth arrest and DNA-damage-inducible, alpha, b. | 0.962 |
TP53 | LOC108231213 | ENSKMAP00000018969 | ENSKMAP00000025778 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Aurora kinase B; Belongs to the protein kinase superfamily. | 0.830 |
TP53 | aurka | ENSKMAP00000018969 | ENSKMAP00000017471 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Aurora kinase A; Belongs to the protein kinase superfamily. | 0.826 |
TP53 | ccnb1 | ENSKMAP00000018969 | ENSKMAP00000011977 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Cyclin B1; Belongs to the cyclin family. | 0.529 |