ENSKMAP00000005929 protein (Kryptolebias marmoratus)

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

ENSKMAP00000005929

Uncharacterized protein. (152 aa)

Predicted Functional Partners:

ENSKMAP00000019427

0.470

MARCO

0.454

ENSKMAP00000009995

0.427

ENSKMAP00000011166

0.426

ENSKMAP00000028282

0.426

LOC108236977

0.417

ENSKMAP00000014252

0.414

scara3

0.414

ENSKMAP00000030115

0.409

c1qtnf2

0.407

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000005929	ENSKMAP00000009995	ENSKMAP00000005929	ENSKMAP00000009995	Uncharacterized protein.	Uncharacterized protein.	0.427
ENSKMAP00000005929	ENSKMAP00000011166	ENSKMAP00000005929	ENSKMAP00000011166	Uncharacterized protein.	Collagen IV NC1 domain-containing protein.	0.426
ENSKMAP00000005929	ENSKMAP00000014252	ENSKMAP00000005929	ENSKMAP00000014252	Uncharacterized protein.	annotation not available	0.414
ENSKMAP00000005929	ENSKMAP00000019427	ENSKMAP00000005929	ENSKMAP00000019427	Uncharacterized protein.	Uncharacterized protein.	0.470
ENSKMAP00000005929	ENSKMAP00000028282	ENSKMAP00000005929	ENSKMAP00000028282	Uncharacterized protein.	Uncharacterized protein.	0.426
ENSKMAP00000005929	ENSKMAP00000030115	ENSKMAP00000005929	ENSKMAP00000030115	Uncharacterized protein.	Si:dkey-21p1.3.	0.409
ENSKMAP00000005929	LOC108236977	ENSKMAP00000005929	ENSKMAP00000015740	Uncharacterized protein.	Collagen, type X, alpha 1a.	0.417
ENSKMAP00000005929	MARCO	ENSKMAP00000005929	ENSKMAP00000004394	Uncharacterized protein.	Macrophage receptor with collagenous structure.	0.454
ENSKMAP00000005929	c1qtnf2	ENSKMAP00000005929	ENSKMAP00000007425	Uncharacterized protein.	C1q and TNF related 2.	0.407
ENSKMAP00000005929	scara3	ENSKMAP00000005929	ENSKMAP00000029959	Uncharacterized protein.	Scavenger receptor class A, member 3.	0.414
ENSKMAP00000009995	ENSKMAP00000005929	ENSKMAP00000009995	ENSKMAP00000005929	Uncharacterized protein.	Uncharacterized protein.	0.427
ENSKMAP00000009995	ENSKMAP00000011166	ENSKMAP00000009995	ENSKMAP00000011166	Uncharacterized protein.	Collagen IV NC1 domain-containing protein.	0.537
ENSKMAP00000009995	ENSKMAP00000014252	ENSKMAP00000009995	ENSKMAP00000014252	Uncharacterized protein.	annotation not available	0.536
ENSKMAP00000009995	ENSKMAP00000019427	ENSKMAP00000009995	ENSKMAP00000019427	Uncharacterized protein.	Uncharacterized protein.	0.540
ENSKMAP00000009995	ENSKMAP00000030115	ENSKMAP00000009995	ENSKMAP00000030115	Uncharacterized protein.	Si:dkey-21p1.3.	0.536
ENSKMAP00000009995	LOC108236977	ENSKMAP00000009995	ENSKMAP00000015740	Uncharacterized protein.	Collagen, type X, alpha 1a.	0.536
ENSKMAP00000011166	ENSKMAP00000005929	ENSKMAP00000011166	ENSKMAP00000005929	Collagen IV NC1 domain-containing protein.	Uncharacterized protein.	0.426
ENSKMAP00000011166	ENSKMAP00000009995	ENSKMAP00000011166	ENSKMAP00000009995	Collagen IV NC1 domain-containing protein.	Uncharacterized protein.	0.537
ENSKMAP00000014252	ENSKMAP00000005929	ENSKMAP00000014252	ENSKMAP00000005929	annotation not available	Uncharacterized protein.	0.414
ENSKMAP00000014252	ENSKMAP00000009995	ENSKMAP00000014252	ENSKMAP00000009995	annotation not available	Uncharacterized protein.	0.536

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

13

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006090

Pyruvate metabolic process

5 of 26

1.78

2.08

2.13e-05

GO:0045454

Cell redox homeostasis

3 of 9

2.02

1.57

0.00084

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

2 of 2

2.5

1.37

0.0030

GO:0006096

Glycolytic process

3 of 18

1.72

1.22

0.0030

GO:0009150

Purine ribonucleotide metabolic process

5 of 79

1.3

1.15

0.00076

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

5 of 7

2.35

3.66

5.65e-08

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

4 of 6

2.32

2.79

3.70e-06

GO:0016417

S-acyltransferase activity

2 of 4

2.2

0.99

0.0147

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.41

0.77

0.0204

GO:0016491

Oxidoreductase activity

8 of 380

0.82

0.71

0.00036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1404

Pyruvate dehydrogenase activity, and e3 binding domain

9 of 13

2.34

7.17

1.15e-16

CL:1406

Pyruvate dehydrogenase activity, and Peptidyl-lysine modification

5 of 5

2.5

4.42

2.31e-09

CL:1367

Mixed, incl. Citrate cycle (TCA cycle), and Oxidoreduction-driven active transmembrane transporter activity

10 of 68

1.66

3.81

5.55e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mvd00020

Citrate cycle (TCA cycle)

7 of 33

1.82

3.53

6.31e-10

mvd00620

Pyruvate metabolism

6 of 54

1.54

2.23

3.78e-07

mvd00010

Glycolysis / Gluconeogenesis

6 of 56

1.53

2.2

3.78e-07

mvd01200

Carbon metabolism

8 of 123

1.31

1.9

3.18e-08

mvd01120

Microbial metabolism in diverse environments

9 of 342

0.92

0.99

1.17e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 17

1.97

2.85

5.77e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00676

Dehydrogenase E1 component

3 of 3

2.5

1.96

0.00023

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 3

2.32

0.9

0.0220

PF02780

Transketolase, C-terminal domain

2 of 4

2.2

0.89

0.0220

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 4

2.2

0.89

0.0220

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 5

2.1

0.89

0.0220

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 14

2.05

2.76

1.62e-06

IPR001017

Dehydrogenase, E1 component

3 of 3

2.5

1.9

0.00030

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.37

1.84

0.00035

IPR005475

Transketolase-like, pyrimidine-binding domain

3 of 6

2.2

1.67

0.00063

IPR023753

FAD/NAD(P)-binding domain

3 of 12

1.89

1.29

0.0027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 6

2.2

1.92

0.00020

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