ENSKMAP00000008701 protein (Kryptolebias marmoratus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSKMAP00000008701

HECT domain-containing protein. (83 aa)

Predicted Functional Partners:

trip12

0.691

LOC108245383

0.538

LOC108248341

0.538

atg7

0.440

uba6

0.414

LOC108231167

0.414

uba1

0.414

zfand4

0.413

uba5

0.411

fau

0.402

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000008701	LOC108231167	ENSKMAP00000008701	ENSKMAP00000008608	HECT domain-containing protein.	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.414
ENSKMAP00000008701	LOC108245383	ENSKMAP00000008701	ENSKMAP00000021539	HECT domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.538
ENSKMAP00000008701	LOC108248341	ENSKMAP00000008701	ENSKMAP00000022818	HECT domain-containing protein.	Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.	0.538
ENSKMAP00000008701	atg7	ENSKMAP00000008701	ENSKMAP00000013981	HECT domain-containing protein.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.440
ENSKMAP00000008701	fau	ENSKMAP00000008701	ENSKMAP00000026703	HECT domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.402
ENSKMAP00000008701	trip12	ENSKMAP00000008701	ENSKMAP00000003839	HECT domain-containing protein.	Thyroid hormone receptor interactor 12.	0.691
ENSKMAP00000008701	uba1	ENSKMAP00000008701	ENSKMAP00000027037	HECT domain-containing protein.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.414
ENSKMAP00000008701	uba5	ENSKMAP00000008701	ENSKMAP00000016439	HECT domain-containing protein.	Ubiquitin-like modifier activating enzyme 5.	0.411
ENSKMAP00000008701	uba6	ENSKMAP00000008701	ENSKMAP00000000027	HECT domain-containing protein.	Ubiquitin like modifier activating enzyme 6.	0.414
ENSKMAP00000008701	zfand4	ENSKMAP00000008701	ENSKMAP00000006476	HECT domain-containing protein.	Zinc finger, AN1-type domain 4.	0.413
LOC108231167	ENSKMAP00000008701	ENSKMAP00000008608	ENSKMAP00000008701	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	HECT domain-containing protein.	0.414
LOC108231167	LOC108245383	ENSKMAP00000008608	ENSKMAP00000021539	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.700
LOC108231167	LOC108248341	ENSKMAP00000008608	ENSKMAP00000022818	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.	0.685
LOC108231167	atg7	ENSKMAP00000008608	ENSKMAP00000013981	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.748
LOC108231167	fau	ENSKMAP00000008608	ENSKMAP00000026703	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.728
LOC108231167	trip12	ENSKMAP00000008608	ENSKMAP00000003839	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Thyroid hormone receptor interactor 12.	0.974
LOC108231167	uba1	ENSKMAP00000008608	ENSKMAP00000027037	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.902
LOC108231167	uba5	ENSKMAP00000008608	ENSKMAP00000016439	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 5.	0.742
LOC108231167	uba6	ENSKMAP00000008608	ENSKMAP00000000027	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 6.	0.908
LOC108231167	zfand4	ENSKMAP00000008608	ENSKMAP00000006476	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	Zinc finger, AN1-type domain 4.	0.732

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.797

expected number of edges:

10

PPI enrichment p-value:

0.00519

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006865

Amino acid transport

6 of 55

1.91

3.07

8.56e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042597

Periplasmic space

6 of 98

1.66

2.51

2.37e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6087

Mixed, incl. Branched-chain amino acid transport, and Nickel cation binding

5 of 36

2.02

2.7

1.99e-06

CL:7456

Mixed, incl. GAF-ANTAR transcription anti-termination regulator, putative, and STAS domain

3 of 6

2.57

2.18

9.16e-05

CL:6089

Mixed, incl. Branched-chain amino acid transport, and Branched-chain amino acid ATP-binding cassette transporter, C-terminal

4 of 26

2.06

2.17

4.30e-05

CL:6091

Branched-chain amino acid transport, and Branched-chain amino acid ATP-binding cassette transporter, C-terminal

3 of 15

2.17

1.75

0.00044

CL:6092

Branched-chain amino acid transport, and Branched-chain amino acid ATP-binding cassette transporter, C-terminal

2 of 10

2.17

0.92

0.0197

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

6 of 491

0.96

0.75

0.0024

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042597

Periplasmic space

6 of 191

1.37

1.56

2.51e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13433

Periplasmic binding protein domain

3 of 3

2.87

2.45

3.28e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR028081

Leucine-binding protein domain

4 of 4

2.87

3.72

1.39e-07

IPR028082

Periplasmic binding protein-like I

6 of 51

1.94

3.12

8.74e-08

IPR012074

GAF-ANTAR transcription anti-termination regulator, putative

3 of 4

2.75

2.36

4.69e-05

IPR005561

ANTAR domain

3 of 5

2.65

2.34

4.69e-05

IPR003018

GAF domain

4 of 28

2.03

2.13

4.69e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01012

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.

3 of 5

2.65

2.57

1.72e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

4 of 34

1.94

2.26

1.72e-05

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