LOC108231426 protein (Kryptolebias marmoratus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LOC108231426

Glutamate receptor, metabotropic 2b. (892 aa)

Predicted Functional Partners:

Wdr90

0.487

GABBR1

0.474

gabbr2

0.469

ENSKMAP00000017340

0.425

GNG4

0.424

grm8

0.424

LOC108239039

0.424

LOC108251226

0.423

LOC108228703

0.419

LOC108244402

0.418

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000017340	GNG4	ENSKMAP00000017340	ENSKMAP00000014472	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.441
ENSKMAP00000017340	LOC108231426	ENSKMAP00000017340	ENSKMAP00000008997	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	Glutamate receptor, metabotropic 2b.	0.425
ENSKMAP00000017340	LOC108239039	ENSKMAP00000017340	ENSKMAP00000021872	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.441
GABBR1	GNG4	ENSKMAP00000012169	ENSKMAP00000014472	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.649
GABBR1	LOC108228703	ENSKMAP00000012169	ENSKMAP00000004390	Gamma-aminobutyric acid (GABA) B receptor, 1a.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.426
GABBR1	LOC108231426	ENSKMAP00000012169	ENSKMAP00000008997	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Glutamate receptor, metabotropic 2b.	0.474
GABBR1	LOC108239039	ENSKMAP00000012169	ENSKMAP00000021872	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.649
GABBR1	LOC108244402	ENSKMAP00000012169	ENSKMAP00000027836	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Glutamate metabotropic receptor 6.	0.426
GABBR1	LOC108251226	ENSKMAP00000012169	ENSKMAP00000019421	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Glutamate metabotropic receptor 7.	0.431
GABBR1	gabbr2	ENSKMAP00000012169	ENSKMAP00000003686	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Gamma-aminobutyric acid (GABA) B receptor, 2.	0.957
GABBR1	grm8	ENSKMAP00000012169	ENSKMAP00000017364	Gamma-aminobutyric acid (GABA) B receptor, 1a.	Glutamate receptor, metabotropic 8a.	0.426
GNG4	ENSKMAP00000017340	ENSKMAP00000014472	ENSKMAP00000017340	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	0.441
GNG4	GABBR1	ENSKMAP00000014472	ENSKMAP00000012169	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Gamma-aminobutyric acid (GABA) B receptor, 1a.	0.649
GNG4	LOC108231426	ENSKMAP00000014472	ENSKMAP00000008997	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Glutamate receptor, metabotropic 2b.	0.424
GNG4	gabbr2	ENSKMAP00000014472	ENSKMAP00000003686	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Gamma-aminobutyric acid (GABA) B receptor, 2.	0.649
LOC108228703	GABBR1	ENSKMAP00000004390	ENSKMAP00000012169	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Gamma-aminobutyric acid (GABA) B receptor, 1a.	0.426
LOC108228703	LOC108231426	ENSKMAP00000004390	ENSKMAP00000008997	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Glutamate receptor, metabotropic 2b.	0.419
LOC108228703	Wdr90	ENSKMAP00000004390	ENSKMAP00000016802	G_PROTEIN_RECEP_F3_4 domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.487
LOC108228703	gabbr2	ENSKMAP00000004390	ENSKMAP00000003686	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Gamma-aminobutyric acid (GABA) B receptor, 2.	0.426
LOC108231426	ENSKMAP00000017340	ENSKMAP00000008997	ENSKMAP00000017340	Glutamate receptor, metabotropic 2b.	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a.	0.425

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

0.00371

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

2 of 2

2.67

1.16

0.0077

GO:0005198

Structural molecule activity

4 of 56

1.52

1.12

0.0032

GO:0003676

Nucleic acid binding

7 of 522

0.8

0.56

0.0077

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043232

Intracellular non-membrane-bounded organelle

4 of 97

1.28

0.92

0.0052

GO:0005694

Chromosome

2 of 29

1.51

0.66

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2589

Mixed, incl. Histone-like DNA-binding protein, and Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

4 of 5

2.57

3.08

1.61e-06

CL:8089

Antiport

2 of 5

2.27

0.81

0.0326

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

2 of 4

2.37

1.03

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

2 of 4

2.37

0.77

0.0397

PF02254

TrkA-N domain

2 of 6

2.19

0.76

0.0397

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010992

Integration host factor (IHF)-like DNA-binding domain superfamily

2 of 2

2.67

0.78

0.0384

IPR000119

Histone-like DNA-binding protein

2 of 2

2.67

0.78

0.0384

IPR006153

Cation/H+ exchanger

2 of 4

2.37

0.77

0.0384

IPR003148

Regulator of K+ conductance, N-terminal

2 of 6

2.19

0.73

0.0446

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00411

Bacterial (prokaryotic) histone like domain

2 of 2

2.67

1.37

0.0032

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