LOC108233721 protein (Kryptolebias marmoratus)

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Known Interactions

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Predicted Interactions

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Score

LOC108233721

UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (562 aa)

Predicted Functional Partners:

LOC108243353

0.924

LOC108244157

0.922

CYP19A1

0.920

LOC108250266

0.918

LOC108247157

0.918

ugdh

0.911

LOC108240983

0.908

LOC108250100

0.908

comt

0.908

LOC108233834

0.906

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP19A1	LOC108233721	ENSKMAP00000029190	ENSKMAP00000010814	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.920
CYP19A1	LOC108240983	ENSKMAP00000029190	ENSKMAP00000000815	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.907
CYP19A1	LOC108243353	ENSKMAP00000029190	ENSKMAP00000002732	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.939
CYP19A1	LOC108244157	ENSKMAP00000029190	ENSKMAP00000010649	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.938
CYP19A1	LOC108247157	ENSKMAP00000029190	ENSKMAP00000021533	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.486
CYP19A1	LOC108250100	ENSKMAP00000029190	ENSKMAP00000022786	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.907
CYP19A1	LOC108250266	ENSKMAP00000029190	ENSKMAP00000002338	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450, family 19, subfamily A, polypeptide 1a.	0.902
LOC108233721	CYP19A1	ENSKMAP00000010814	ENSKMAP00000029190	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.920
LOC108233721	LOC108233834	ENSKMAP00000010814	ENSKMAP00000017204	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.906
LOC108233721	LOC108240983	ENSKMAP00000010814	ENSKMAP00000000815	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Aldo_ket_red domain-containing protein.	0.908
LOC108233721	LOC108243353	ENSKMAP00000010814	ENSKMAP00000002732	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.924
LOC108233721	LOC108244157	ENSKMAP00000010814	ENSKMAP00000010649	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.922
LOC108233721	LOC108247157	ENSKMAP00000010814	ENSKMAP00000021533	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.918
LOC108233721	LOC108250100	ENSKMAP00000010814	ENSKMAP00000022786	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Aldo_ket_red domain-containing protein.	0.908
LOC108233721	LOC108250266	ENSKMAP00000010814	ENSKMAP00000002338	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450, family 19, subfamily A, polypeptide 1a.	0.918
LOC108233721	comt	ENSKMAP00000010814	ENSKMAP00000027859	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	Catechol-O-methyltransferase b.	0.908
LOC108233721	ugdh	ENSKMAP00000010814	ENSKMAP00000000052	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.911
LOC108233834	LOC108233721	ENSKMAP00000017204	ENSKMAP00000010814	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.906
LOC108240983	CYP19A1	ENSKMAP00000000815	ENSKMAP00000029190	Aldo_ket_red domain-containing protein.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.907
LOC108240983	LOC108233721	ENSKMAP00000000815	ENSKMAP00000010814	Aldo_ket_red domain-containing protein.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.908

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Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.822

expected number of edges:

7

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

6 of 8

2.58

5.47

1.97e-11

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 22

2.21

4.91

1.97e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 170

1.38

2.12

1.19e-08

GO:0006520

Cellular amino acid metabolic process

9 of 265

1.24

1.79

6.71e-09

GO:1901605

Alpha-amino acid metabolic process

7 of 191

1.27

1.63

1.03e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 143

1.33

1.38

0.00010

GO:0046820

4-amino-4-deoxychorismate synthase activity

2 of 2

2.71

1.14

0.0084

GO:0004834

Tryptophan synthase activity

2 of 3

2.53

1.14

0.0084

GO:0004048

Anthranilate phosphoribosyltransferase activity

2 of 2

2.71

1.14

0.0084

GO:0016835

Carbon-oxygen lyase activity

3 of 64

1.38

0.65

0.0401

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

Aromatic amino acid biosynthesis, and DAHP synthetase I/KDSA

10 of 19

2.43

8.78

3.27e-20

CL:2307

Tryptophan biosynthesis

6 of 6

2.71

6.06

2.08e-12

CL:2211

Mixed, incl. Amino-acid biosynthesis, and Vitamin B6 binding

11 of 94

1.78

4.87

1.82e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

7 of 34

2.02

4.43

2.83e-11

map01230

Biosynthesis of amino acids

8 of 205

1.3

1.86

3.81e-08

map00790

Folate biosynthesis

3 of 56

1.44

0.98

0.0058

map01110

Biosynthesis of secondary metabolites

8 of 771

0.72

0.6

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1516

0.53

0.39

0.0053

GOCC:0005622

Intracellular

11 of 2067

0.43

0.34

0.0053

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

7 of 8

2.65

7.17

6.53e-15

KW-0057

Aromatic amino acid biosynthesis

8 of 18

2.36

6.75

2.25e-15

KW-0028

Amino-acid biosynthesis

9 of 69

1.82

4.49

4.62e-14

KW-0456

Lyase

6 of 92

1.52

2.16

5.61e-07

KW-0315

Glutamine amidotransferase

2 of 14

1.86

0.91

0.0178

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

3 of 3

2.71

2.22

8.21e-05

PF00425

Chorismate binding enzyme

3 of 4

2.58

2.2

8.21e-05

PF00591

Glycosyl transferase family, a/b domain

2 of 3

2.53

1.13

0.0085

PF07722

Peptidase C26

2 of 5

2.31

1.01

0.0134

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019999

Anthranilate synthase component I-like

3 of 3

2.71

2.01

0.00021

IPR006805

Anthranilate synthase component I, N-terminal

3 of 3

2.71

2.01

0.00021

IPR015890

Chorismate-utilising enzyme, C-terminal

3 of 4

2.58

1.99

0.00021

IPR005801

ADC synthase

3 of 4

2.58

1.99

0.00021

IPR006221

Anthranilate synthase/para-aminobenzoate synthase like domain

2 of 2

2.71

1.16

0.0078

(more ...)

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