sugt1 protein (Kryptolebias marmoratus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

sugt1

SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (323 aa)

Predicted Functional Partners:

hsp90ab1

0.988

LOC108231826

0.988

LOC108231827

0.988

skp1

0.957

LOC108250425

0.940

nod1

0.940

hsp90b1

0.899

ENSKMAP00000008344

0.853

trap1

0.853

ENSKMAP00000021560

0.853

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000008344	ENSKMAP00000021560	ENSKMAP00000008344	ENSKMAP00000021560	Uncharacterized protein.	Uncharacterized protein.	0.901
ENSKMAP00000008344	sugt1	ENSKMAP00000008344	ENSKMAP00000011214	Uncharacterized protein.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.853
ENSKMAP00000021560	ENSKMAP00000008344	ENSKMAP00000021560	ENSKMAP00000008344	Uncharacterized protein.	Uncharacterized protein.	0.901
ENSKMAP00000021560	sugt1	ENSKMAP00000021560	ENSKMAP00000011214	Uncharacterized protein.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.853
LOC108231826	LOC108231827	ENSKMAP00000026414	ENSKMAP00000026473	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.900
LOC108231826	hsp90ab1	ENSKMAP00000026414	ENSKMAP00000025352	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	HATPase_c domain-containing protein.	0.936
LOC108231826	sugt1	ENSKMAP00000026414	ENSKMAP00000011214	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.988
LOC108231827	LOC108231826	ENSKMAP00000026473	ENSKMAP00000026414	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.900
LOC108231827	hsp90ab1	ENSKMAP00000026473	ENSKMAP00000025352	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	HATPase_c domain-containing protein.	0.936
LOC108231827	sugt1	ENSKMAP00000026473	ENSKMAP00000011214	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.988
LOC108250425	nod1	ENSKMAP00000008195	ENSKMAP00000022475	Uncharacterized protein.	Nucleotide-binding oligomerization domain containing 1.	0.926
LOC108250425	sugt1	ENSKMAP00000008195	ENSKMAP00000011214	Uncharacterized protein.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.940
hsp90ab1	LOC108231826	ENSKMAP00000025352	ENSKMAP00000026414	HATPase_c domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.936
hsp90ab1	LOC108231827	ENSKMAP00000025352	ENSKMAP00000026473	HATPase_c domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.936
hsp90ab1	sugt1	ENSKMAP00000025352	ENSKMAP00000011214	HATPase_c domain-containing protein.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.988
hsp90b1	skp1	ENSKMAP00000004240	ENSKMAP00000026700	Heat shock protein 90, beta (grp94), member 1.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.427
hsp90b1	sugt1	ENSKMAP00000004240	ENSKMAP00000011214	Heat shock protein 90, beta (grp94), member 1.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.899
nod1	LOC108250425	ENSKMAP00000022475	ENSKMAP00000008195	Nucleotide-binding oligomerization domain containing 1.	Uncharacterized protein.	0.926
nod1	sugt1	ENSKMAP00000022475	ENSKMAP00000011214	Nucleotide-binding oligomerization domain containing 1.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.940
skp1	hsp90b1	ENSKMAP00000026700	ENSKMAP00000004240	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	Heat shock protein 90, beta (grp94), member 1.	0.427

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.904

expected number of edges:

11

PPI enrichment p-value:

0.00438

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 69

1.57

2.69

4.64e-09

GO:0000160

Phosphorelay signal transduction system

9 of 120

1.39

2.19

4.64e-09

GO:0050896

Response to stimulus

11 of 336

1.03

1.3

4.64e-09

GO:0050794

Regulation of cellular process

11 of 352

1.01

1.26

4.64e-09

GO:0006355

Regulation of transcription, DNA-templated

8 of 222

1.07

1.22

2.30e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043565

Sequence-specific DNA binding

7 of 50

1.66

2.88

5.80e-09

GO:0000155

Phosphorelay sensor kinase activity

8 of 73

1.55

2.63

4.72e-09

GO:0003700

DNA-binding transcription factor activity

7 of 93

1.39

1.96

2.24e-07

GO:0003677

DNA binding

8 of 281

0.96

1.0

1.05e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

7 of 32

1.85

3.66

3.79e-10

GO:0016021

Integral component of membrane

10 of 699

0.67

0.59

4.59e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3690

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

10 of 46

1.85

4.83

3.36e-15

CL:3697

PAS domain, and cheY-homologous receiver domain

8 of 28

1.97

4.77

5.44e-13

CL:3691

PAS domain, and cheY-homologous receiver domain

9 of 41

1.85

4.58

5.96e-14

CL:3699

PAS domain, and cheY-homologous receiver domain

6 of 21

1.97

3.74

1.61e-09

CL:3702

PAS domain, and cheY-homologous receiver domain

5 of 16

2.01

3.26

6.33e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 403

0.95

1.13

5.70e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 127

1.36

2.18

1.35e-09

KW-0597

Phosphoprotein

6 of 74

1.42

1.79

4.45e-06

KW-0067

ATP-binding

7 of 215

1.02

1.03

4.39e-05

KW-0902

Two-component regulatory system

2 of 12

1.73

0.84

0.0222

KW-0175

Coiled coil

6 of 248

0.89

0.73

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 44

1.82

4.18

1.25e-12

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

9 of 51

1.76

3.9

2.08e-12

IPR005467

Histidine kinase domain

9 of 52

1.75

3.87

2.08e-12

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

9 of 54

1.73

3.81

2.08e-12

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 60

1.69

3.61

3.17e-12

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

10 of 60

1.73

4.27

4.94e-15

SM00387

Histidine kinase-like ATPases

9 of 63

1.67

3.62

9.28e-13

SM00091

PAS domain

6 of 26

1.87

3.4

4.98e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 24

1.83

2.77

2.90e-07

SM00448

cheY-homologous receiver domain

6 of 68

1.46

2.03

5.81e-07

(more ...)

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