LOC108228931 protein (Kryptolebias marmoratus)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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co-expression

protein homology

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Score

LOC108228931

Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (960 aa)

Predicted Functional Partners:

DSC1

0.712

LOC108236365

0.685

LOC108235040

0.670

LOC108231698

0.578

PKP1

0.578

LOC108237871

0.556

PKP3

0.556

LOC108241224

0.516

ctnnb1

0.516

LOC108239610

0.503

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DSC1	LOC108228931	ENSKMAP00000018900	ENSKMAP00000011409	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.712
DSC1	LOC108231698	ENSKMAP00000018900	ENSKMAP00000021279	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 1b.	0.720
DSC1	LOC108235040	ENSKMAP00000018900	ENSKMAP00000018434	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.844
DSC1	LOC108236365	ENSKMAP00000018900	ENSKMAP00000026995	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin a.	0.908
DSC1	LOC108237871	ENSKMAP00000018900	ENSKMAP00000017576	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3b.	0.681
DSC1	LOC108239610	ENSKMAP00000018900	ENSKMAP00000019288	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoplakin a.	0.527
DSC1	LOC108241224	ENSKMAP00000018900	ENSKMAP00000003086	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.760
DSC1	PKP1	ENSKMAP00000018900	ENSKMAP00000027444	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 1.	0.719
DSC1	PKP3	ENSKMAP00000018900	ENSKMAP00000028853	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3.	0.681
DSC1	ctnnb1	ENSKMAP00000018900	ENSKMAP00000028720	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Catenin (cadherin-associated protein), beta 1.	0.760
LOC108228931	DSC1	ENSKMAP00000011409	ENSKMAP00000018900	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.712
LOC108228931	LOC108231698	ENSKMAP00000011409	ENSKMAP00000021279	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 1b.	0.578
LOC108228931	LOC108235040	ENSKMAP00000011409	ENSKMAP00000018434	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.670
LOC108228931	LOC108236365	ENSKMAP00000011409	ENSKMAP00000026995	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin a.	0.685
LOC108228931	LOC108237871	ENSKMAP00000011409	ENSKMAP00000017576	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3b.	0.556
LOC108228931	LOC108239610	ENSKMAP00000011409	ENSKMAP00000019288	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoplakin a.	0.503
LOC108228931	LOC108241224	ENSKMAP00000011409	ENSKMAP00000003086	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.516
LOC108228931	PKP1	ENSKMAP00000011409	ENSKMAP00000027444	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 1.	0.578
LOC108228931	PKP3	ENSKMAP00000011409	ENSKMAP00000028853	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3.	0.556
LOC108228931	ctnnb1	ENSKMAP00000011409	ENSKMAP00000028720	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Catenin (cadherin-associated protein), beta 1.	0.516

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.906

expected number of edges:

29

PPI enrichment p-value:

0.282

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

5 of 108

1.21

0.8

0.0098

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004252

Serine-type endopeptidase activity

5 of 35

1.7

1.96

2.74e-05

GO:0047617

acyl-CoA hydrolase activity

2 of 3

2.37

1.13

0.0082

GO:0016787

Hydrolase activity

8 of 654

0.63

0.45

0.0082

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1525

Mostly uncharacterized, incl. KR domain, and Trypsin-like peptidase domain

6 of 53

1.6

2.09

3.84e-06

CL:1583

Trypsin-like peptidase domain, and Antigen processing-Cross presentation

3 of 5

2.32

1.99

0.00017

CL:1528

Mixed, incl. Trypsin-like peptidase domain, and KR domain

5 of 38

1.66

1.93

2.66e-05

CL:2514

Mixed, incl. CoA hydrolase activity, and Lipoprotein

2 of 6

2.07

0.84

0.0263

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042597

Periplasmic space

4 of 95

1.17

0.62

0.0324

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13365

Trypsin-like peptidase domain

5 of 5

2.54

4.18

8.68e-09

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00228

Domain present in PSD-95, Dlg, and ZO-1/2.

3 of 5

2.32

2.08

0.00011

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