LOC108228211 protein (Kryptolebias marmoratus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

LOC108228211

Mical-like 2b. (959 aa)

Predicted Functional Partners:

rab13

0.923

rab8b

0.923

LOC108232971

0.923

rab8a

0.923

ACTN4

0.912

actn1

0.912

micall2

0.907

LOC108249344

0.568

CASK

0.568

capzb

0.520

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN4	CASK	ENSKMAP00000003269	ENSKMAP00000014448	Actinin alpha 4.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.568
ACTN4	LOC108228211	ENSKMAP00000003269	ENSKMAP00000013409	Actinin alpha 4.	Mical-like 2b.	0.912
ACTN4	LOC108249344	ENSKMAP00000003269	ENSKMAP00000014393	Actinin alpha 4.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.568
ACTN4	actn1	ENSKMAP00000003269	ENSKMAP00000020464	Actinin alpha 4.	Actinin, alpha 1.	0.900
ACTN4	capzb	ENSKMAP00000003269	ENSKMAP00000029099	Actinin alpha 4.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.635
ACTN4	micall2	ENSKMAP00000003269	ENSKMAP00000025644	Actinin alpha 4.	Mical-like 2a.	0.912
CASK	ACTN4	ENSKMAP00000014448	ENSKMAP00000003269	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Actinin alpha 4.	0.568
CASK	LOC108228211	ENSKMAP00000014448	ENSKMAP00000013409	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Mical-like 2b.	0.568
CASK	LOC108249344	ENSKMAP00000014448	ENSKMAP00000014393	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.741
CASK	actn1	ENSKMAP00000014448	ENSKMAP00000020464	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Actinin, alpha 1.	0.568
CASK	micall2	ENSKMAP00000014448	ENSKMAP00000025644	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Mical-like 2a.	0.568
LOC108228211	ACTN4	ENSKMAP00000013409	ENSKMAP00000003269	Mical-like 2b.	Actinin alpha 4.	0.912
LOC108228211	CASK	ENSKMAP00000013409	ENSKMAP00000014448	Mical-like 2b.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.568
LOC108228211	LOC108232971	ENSKMAP00000013409	ENSKMAP00000028903	Mical-like 2b.	RAB8A, member RAS oncogene family.	0.923
LOC108228211	LOC108249344	ENSKMAP00000013409	ENSKMAP00000014393	Mical-like 2b.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.568
LOC108228211	actn1	ENSKMAP00000013409	ENSKMAP00000020464	Mical-like 2b.	Actinin, alpha 1.	0.912
LOC108228211	capzb	ENSKMAP00000013409	ENSKMAP00000029099	Mical-like 2b.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.520
LOC108228211	micall2	ENSKMAP00000013409	ENSKMAP00000025644	Mical-like 2b.	Mical-like 2a.	0.907
LOC108228211	rab13	ENSKMAP00000013409	ENSKMAP00000002507	Mical-like 2b.	RAB13, member RAS oncogene family.	0.923
LOC108228211	rab8a	ENSKMAP00000013409	ENSKMAP00000030173	Mical-like 2b.	RAB8A, member RAS oncogene family.	0.923

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.872

expected number of edges:

14

PPI enrichment p-value:

0.000424

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000271

Polysaccharide biosynthetic process

6 of 59

1.59

2.18

1.58e-06

GO:0009252

Peptidoglycan biosynthetic process

4 of 28

1.74

1.85

7.57e-05

GO:0008360

Regulation of cell shape

4 of 28

1.74

1.85

7.57e-05

GO:0071555

Cell wall organization

4 of 31

1.7

1.81

7.57e-05

GO:0033692

Cellular polysaccharide biosynthetic process

5 of 55

1.54

1.78

2.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

3 of 14

1.92

1.11

0.0068

GO:0016757

Glycosyltransferase activity

4 of 70

1.34

0.86

0.0101

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3065

Mixed, incl. Nucleotide-diphospho-sugar transferases, and O-Antigen nucleotide sugar biosynthesis

7 of 44

1.79

3.17

6.83e-09

CL:2321

Mur ligase, C-terminal, and Glycosyl transferase family 4

4 of 6

2.41

3.16

7.73e-07

CL:3067

Mixed, incl. Nucleotide-diphospho-sugar transferases, and Streptomycin biosynthesis

4 of 31

1.7

1.77

0.00010

CL:3071

Mixed, incl. Polyketide sugar unit biosynthesis, and Glycosyltransferase like family 2

3 of 12

1.98

1.72

0.00037

CL:3073

Glycosyltransferase like family 2, and ABC-2 type transporter

2 of 5

2.19

1.17

0.0065

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

4 of 28

1.74

1.79

0.00011

map01502

Vancomycin resistance

2 of 9

1.93

0.96

0.0146

map01100

Metabolic pathways

10 of 1471

0.42

0.31

0.0129

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

4 of 18

1.93

2.09

4.22e-05

KW-0961

Cell wall biogenesis/degradation

4 of 21

1.87

2.04

4.22e-05

KW-0132

Cell division

4 of 38

1.61

1.62

0.00016

KW-0131

Cell cycle

4 of 38

1.61

1.62

0.00016

KW-0436

Ligase

3 of 84

1.14

0.58

0.0422

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 4

2.46

1.9

0.00029

PF08245

Mur ligase middle domain

3 of 5

2.36

1.88

0.00029

PF01225

Mur ligase family, catalytic domain

2 of 3

2.41

1.03

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004101

Mur ligase, C-terminal

3 of 4

2.46

1.69

0.00074

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.36

1.67

0.00074

IPR036565

Mur-like, catalytic domain superfamily

3 of 5

2.36

1.67

0.00074

IPR013221

Mur ligase, central

3 of 5

2.36

1.67

0.00074

IPR001173

Glycosyltransferase 2-like

3 of 9

2.11

1.57

0.00092

(more ...)

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