CHUK protein (Kryptolebias marmoratus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

CHUK

Component of inhibitor of nuclear factor kappa B kinase complex. (768 aa)

Predicted Functional Partners:

ikbkg

0.986

traf6

0.984

map3k14

0.981

tab2

0.972

ripk1

0.967

nfkb2

0.964

tab1

0.963

LOC108231757

0.961

nfkbia

0.961

nfkbie

0.961

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	LOC108231757	ENSKMAP00000016900	ENSKMAP00000004898	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.961
CHUK	ikbkg	ENSKMAP00000016900	ENSKMAP00000007443	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.986
CHUK	map3k14	ENSKMAP00000016900	ENSKMAP00000024805	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 14a.	0.981
CHUK	nfkb2	ENSKMAP00000016900	ENSKMAP00000003936	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.964
CHUK	nfkbia	ENSKMAP00000016900	ENSKMAP00000011039	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.961
CHUK	nfkbie	ENSKMAP00000016900	ENSKMAP00000025077	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon.	0.961
CHUK	ripk1	ENSKMAP00000016900	ENSKMAP00000020156	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.967
CHUK	tab1	ENSKMAP00000016900	ENSKMAP00000015046	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.963
CHUK	tab2	ENSKMAP00000016900	ENSKMAP00000019416	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.972
CHUK	traf6	ENSKMAP00000016900	ENSKMAP00000004164	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.984
LOC108231757	CHUK	ENSKMAP00000004898	ENSKMAP00000016900	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.961
LOC108231757	ikbkg	ENSKMAP00000004898	ENSKMAP00000007443	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.928
LOC108231757	map3k14	ENSKMAP00000004898	ENSKMAP00000024805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Mitogen-activated protein kinase kinase kinase 14a.	0.593
LOC108231757	nfkb2	ENSKMAP00000004898	ENSKMAP00000003936	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.881
LOC108231757	nfkbia	ENSKMAP00000004898	ENSKMAP00000011039	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.903
LOC108231757	nfkbie	ENSKMAP00000004898	ENSKMAP00000025077	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon.	0.917
LOC108231757	traf6	ENSKMAP00000004898	ENSKMAP00000004164	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.724
ikbkg	CHUK	ENSKMAP00000007443	ENSKMAP00000016900	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.986
ikbkg	LOC108231757	ENSKMAP00000007443	ENSKMAP00000004898	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.928
ikbkg	map3k14	ENSKMAP00000007443	ENSKMAP00000024805	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Mitogen-activated protein kinase kinase kinase 14a.	0.922

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Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.564

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055071

Manganese ion homeostasis

2 of 3

3.57

2.33

0.0020

GO:0033212

Iron import into cell

2 of 5

3.35

2.3

0.0021

GO:0071578

Zinc ion import across plasma membrane

2 of 8

3.14

2.29

0.0021

GO:0006882

Cellular zinc ion homeostasis

2 of 23

2.68

1.84

0.0066

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015086

Cadmium ion transmembrane transporter activity

2 of 6

3.27

2.38

0.0017

GO:0005384

Manganese ion transmembrane transporter activity

2 of 11

3.0

2.36

0.0017

GO:0005381

Iron ion transmembrane transporter activity

2 of 9

3.09

2.36

0.0017

GO:0015296

Anion:cation symporter activity

2 of 18

2.79

2.15

0.0028

GO:0005385

Zinc ion transmembrane transporter activity

2 of 26

2.63

1.96

0.0045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25082

Zinc ion transport

2 of 18

2.79

1.55

0.0151

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tgu04216

Ferroptosis

2 of 28

2.6

2.32

0.0016

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-442380

Zinc influx into cells by the SLC39 gene family

2 of 17

2.81

1.87

0.0062

MAP-435354

Zinc transporters

2 of 25

2.65

1.84

0.0064

MAP-425410

Metal ion SLC transporters

2 of 38

2.46

1.68

0.0094

MAP-425366

Transport of bile salts and organic acids, metal ions and amine compounds

2 of 96

2.06

1.1

0.0429

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009925

Basal plasma membrane

2 of 44

2.4

1.21

0.0356

GOCC:0005765

Lysosomal membrane

2 of 69

2.21

1.19

0.0356

GOCC:0045177

Apical part of cell

2 of 97

2.06

1.16

0.0356

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