lpar1 protein (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

lpar1

Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)

Predicted Functional Partners:

LOC108239985

0.952

LOC108231398

0.952

gna12

0.952

gna13

0.952

LOC108233300

0.952

LOC108236783

0.952

LOC108235740

0.952

gnb1

0.682

LOC108231344

0.682

LOC108248275

0.682

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108231344	LOC108231398	ENSKMAP00000007850	ENSKMAP00000008692	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.706
LOC108231344	LOC108233300	ENSKMAP00000007850	ENSKMAP00000015252	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Uncharacterized protein.	0.706
LOC108231344	LOC108235740	ENSKMAP00000007850	ENSKMAP00000027408	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.706
LOC108231344	LOC108236783	ENSKMAP00000007850	ENSKMAP00000023384	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.706
LOC108231344	LOC108239985	ENSKMAP00000007850	ENSKMAP00000007502	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Uncharacterized protein.	0.706
LOC108231344	gna12	ENSKMAP00000007850	ENSKMAP00000010110	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	G protein subunit alpha 12.	0.707
LOC108231344	gna13	ENSKMAP00000007850	ENSKMAP00000011859	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Guanine nucleotide binding protein (G protein), alpha 13b.	0.707
LOC108231344	gnb1	ENSKMAP00000007850	ENSKMAP00000004813	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.900
LOC108231344	lpar1	ENSKMAP00000007850	ENSKMAP00000020795	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.682
LOC108231398	LOC108231344	ENSKMAP00000008692	ENSKMAP00000007850	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.706
LOC108231398	LOC108248275	ENSKMAP00000008692	ENSKMAP00000019044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.706
LOC108231398	gnb1	ENSKMAP00000008692	ENSKMAP00000004813	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.706
LOC108231398	lpar1	ENSKMAP00000008692	ENSKMAP00000020795	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.952
LOC108233300	LOC108231344	ENSKMAP00000015252	ENSKMAP00000007850	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.706
LOC108233300	LOC108248275	ENSKMAP00000015252	ENSKMAP00000019044	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.706
LOC108233300	gnb1	ENSKMAP00000015252	ENSKMAP00000004813	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.706
LOC108233300	lpar1	ENSKMAP00000015252	ENSKMAP00000020795	Uncharacterized protein.	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.952
LOC108235740	LOC108231344	ENSKMAP00000027408	ENSKMAP00000007850	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.706
LOC108235740	LOC108248275	ENSKMAP00000027408	ENSKMAP00000019044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.706
LOC108235740	gnb1	ENSKMAP00000027408	ENSKMAP00000004813	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.706

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.908

expected number of edges:

10

PPI enrichment p-value:

9.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006011

UDP-glucose metabolic process

2 of 2

2.27

0.91

0.0211

GO:0009225

Nucleotide-sugar metabolic process

3 of 12

1.66

0.89

0.0160

GO:0005975

Carbohydrate metabolic process

8 of 163

0.96

0.87

0.00026

GO:0000271

Polysaccharide biosynthetic process

4 of 35

1.32

0.78

0.0160

GO:0005978

Glycogen biosynthetic process

2 of 4

1.97

0.78

0.0331

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016779

Nucleotidyltransferase activity

5 of 42

1.34

1.14

0.0012

GO:0008878

glucose-1-phosphate adenylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0003983

UTP:glucose-1-phosphate uridylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0004645

1,4-alpha-oligoglucan phosphorylase activity

2 of 3

2.09

0.74

0.0421

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031470

Carboxysome

2 of 2

2.27

0.98

0.0154

GO:0045121

Membrane raft

2 of 5

1.87

0.91

0.0178

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2250

Starch and sucrose metabolism, and Alpha-amylase domain

6 of 24

1.66

2.32

1.22e-06

CL:2282

Glycogen metabolic process

3 of 5

2.04

1.71

0.00043

CL:2034

Mixed, incl. Carbohydrate transport, and Microbial metabolism in diverse environments

7 of 132

0.99

0.94

0.00014

CL:2032

Carbohydrate transport, and Carbohydrate metabolic process

8 of 166

0.95

0.91

7.39e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagl00500

Starch and sucrose metabolism

7 of 26

1.7

3.01

4.31e-09

lagl00520

Amino sugar and nucleotide sugar metabolism

6 of 26

1.63

2.48

1.84e-07

lagl00052

Galactose metabolism

4 of 10

1.87

2.23

1.38e-05

lagl00541

O-Antigen nucleotide sugar biosynthesis

4 of 11

1.83

2.19

1.41e-05

lagl00040

Pentose and glucuronate interconversions

2 of 3

2.09

1.29

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0010170

glucose-1-phosphate adenylyltransferase complex

2 of 2

2.27

0.8

0.0331

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

5 of 26

1.55

1.73

4.38e-05

KW-0119

Carbohydrate metabolism

3 of 14

1.6

1.03

0.0066

KW-0808

Transferase

7 of 240

0.73

0.52

0.0066

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12804

MobA-like NTP transferase domain

4 of 5

2.17

2.39

1.90e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005835

Nucleotidyl transferase domain

5 of 5

2.27

3.26

3.06e-07

IPR029044

Nucleotide-diphospho-sugar transferases

5 of 21

1.64

1.85

3.84e-05

IPR011832

Glucose-1-phosphate adenylyltransferase, GlgD subunit

2 of 2

2.27

0.76

0.0411

IPR011831

Glucose-1-phosphate adenylyltransferase

2 of 2

2.27

0.76

0.0411

IPR005771

UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type

2 of 2

2.27

0.76

0.0411

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About