psap protein (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

psap

Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (536 aa)

Predicted Functional Partners:

LOC108234611

0.900

LOC108235116

0.801

galc

0.758

gba

0.680

tmem130

0.679

chid1

0.619

LOC108237382

0.606

LOC108240069

0.601

LOC108228642

0.584

gpr37

0.584

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108228642	LOC108234611	ENSKMAP00000002643	ENSKMAP00000024579	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Surfactant protein Bb.	0.584
LOC108228642	psap	ENSKMAP00000002643	ENSKMAP00000021238	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.584
LOC108234611	LOC108228642	ENSKMAP00000024579	ENSKMAP00000002643	Surfactant protein Bb.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.584
LOC108234611	LOC108235116	ENSKMAP00000024579	ENSKMAP00000017491	Surfactant protein Bb.	G protein-coupled receptor 37b.	0.584
LOC108234611	LOC108237382	ENSKMAP00000024579	ENSKMAP00000026912	Surfactant protein Bb.	Cathepsin Ba; Belongs to the peptidase C1 family.	0.606
LOC108234611	LOC108240069	ENSKMAP00000024579	ENSKMAP00000016411	Surfactant protein Bb.	Cathepsin Bb; Belongs to the peptidase C1 family.	0.601
LOC108234611	chid1	ENSKMAP00000024579	ENSKMAP00000027427	Surfactant protein Bb.	Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family.	0.619
LOC108234611	galc	ENSKMAP00000024579	ENSKMAP00000002182	Surfactant protein Bb.	Galactosylceramidase b.	0.758
LOC108234611	gba	ENSKMAP00000024579	ENSKMAP00000002200	Surfactant protein Bb.	Glucosylceramidase.	0.680
LOC108234611	gpr37	ENSKMAP00000024579	ENSKMAP00000008526	Surfactant protein Bb.	G protein-coupled receptor 37a.	0.584
LOC108234611	psap	ENSKMAP00000024579	ENSKMAP00000021238	Surfactant protein Bb.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.900
LOC108234611	tmem130	ENSKMAP00000024579	ENSKMAP00000010970	Surfactant protein Bb.	Transmembrane protein 130.	0.679
LOC108235116	LOC108234611	ENSKMAP00000017491	ENSKMAP00000024579	G protein-coupled receptor 37b.	Surfactant protein Bb.	0.584
LOC108235116	psap	ENSKMAP00000017491	ENSKMAP00000021238	G protein-coupled receptor 37b.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.801
LOC108237382	LOC108234611	ENSKMAP00000026912	ENSKMAP00000024579	Cathepsin Ba; Belongs to the peptidase C1 family.	Surfactant protein Bb.	0.606
LOC108237382	LOC108240069	ENSKMAP00000026912	ENSKMAP00000016411	Cathepsin Ba; Belongs to the peptidase C1 family.	Cathepsin Bb; Belongs to the peptidase C1 family.	0.901
LOC108237382	psap	ENSKMAP00000026912	ENSKMAP00000021238	Cathepsin Ba; Belongs to the peptidase C1 family.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.606
LOC108240069	LOC108234611	ENSKMAP00000016411	ENSKMAP00000024579	Cathepsin Bb; Belongs to the peptidase C1 family.	Surfactant protein Bb.	0.601
LOC108240069	LOC108237382	ENSKMAP00000016411	ENSKMAP00000026912	Cathepsin Bb; Belongs to the peptidase C1 family.	Cathepsin Ba; Belongs to the peptidase C1 family.	0.901
LOC108240069	psap	ENSKMAP00000016411	ENSKMAP00000021238	Cathepsin Bb; Belongs to the peptidase C1 family.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.601

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.916

expected number of edges:

29

PPI enrichment p-value:

0.0016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006544

Glycine metabolic process

4 of 8

2.2

2.29

3.30e-05

GO:0019464

Glycine decarboxylation via glycine cleavage system

3 of 4

2.37

1.76

0.00051

GO:0006189

De novo IMP biosynthetic process

3 of 14

1.83

1.39

0.0015

GO:0035999

Tetrahydrofolate interconversion

2 of 3

2.32

1.31

0.0037

GO:0009156

Ribonucleoside monophosphate biosynthetic process

4 of 37

1.53

1.29

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

4 of 8

2.2

2.41

1.84e-05

GO:0016741

Transferase activity, transferring one-carbon groups

5 of 61

1.41

1.36

0.00031

GO:0019238

Cyclohydrolase activity

2 of 5

2.1

0.73

0.0440

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005960

Glycine cleavage complex

2 of 3

2.32

1.22

0.0055

GO:0005829

Cytosol

7 of 303

0.86

0.71

0.0012

GO:0005737

Cytoplasm

9 of 1173

0.38

0.26

0.0472

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31410034

(2019) Staphyloxanthin: a potential target for antivirulence therapy.

3 of 10

1.98

1.56

0.00079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1866

Glycine catabolic process

4 of 5

2.4

2.76

5.29e-06

CL:839

De novo IMP biosynthetic process

3 of 8

2.07

1.61

0.00075

CL:834

Nucleoside monophosphate biosynthetic process, and Pyrimidine metabolism

4 of 57

1.35

0.99

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

5 of 17

1.97

2.95

3.19e-07

map00260

Glycine, serine and threonine metabolism

4 of 46

1.44

1.37

0.00033

map00630

Glyoxylate and dicarboxylate metabolism

4 of 49

1.41

1.35

0.00033

map01200

Carbon metabolism

6 of 114

1.22

1.33

3.39e-05

map01110

Biosynthesis of secondary metabolites

8 of 436

0.76

0.66

0.00029

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005960

Glycine cleavage complex

2 of 3

2.32

0.88

0.0239

GOCC:0005737

Cytoplasm

9 of 946

0.48

0.31

0.0352

GOCC:0005622

Intracellular

10 of 1285

0.39

0.28

0.0352

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 17

1.87

1.96

6.97e-05

KW-0554

One-carbon metabolism

2 of 5

2.1

0.9

0.0210

KW-0511

Multifunctional enzyme

2 of 10

1.8

0.71

0.0436

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About