rpusd1 protein (Kryptolebias marmoratus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

rpusd1

RNA pseudouridine synthase domain containing 1. (305 aa)

Predicted Functional Partners:

ENSKMAP00000019562

0.863

gtpbp3

0.849

mrm3

0.819

pus7l

0.810

gtpbp8

0.805

rpl23

0.795

mrpl21

0.794

mrpl17

0.793

mrpl3

0.780

mtg1

0.775

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000019562	gtpbp3	ENSKMAP00000019562	ENSKMAP00000005199	Si:zfos-1192g2.3.	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	0.863
ENSKMAP00000019562	gtpbp8	ENSKMAP00000019562	ENSKMAP00000027108	Si:zfos-1192g2.3.	EngB-type G domain-containing protein.	0.913
ENSKMAP00000019562	mrm3	ENSKMAP00000019562	ENSKMAP00000025730	Si:zfos-1192g2.3.	Mitochondrial rRNA methyltransferase 3a.	0.978
ENSKMAP00000019562	mrpl17	ENSKMAP00000019562	ENSKMAP00000015003	Si:zfos-1192g2.3.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.986
ENSKMAP00000019562	mrpl21	ENSKMAP00000019562	ENSKMAP00000027169	Si:zfos-1192g2.3.	Mitochondrial ribosomal protein L21.	0.988
ENSKMAP00000019562	mrpl3	ENSKMAP00000019562	ENSKMAP00000002851	Si:zfos-1192g2.3.	Mitochondrial ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.953
ENSKMAP00000019562	mtg1	ENSKMAP00000019562	ENSKMAP00000027038	Si:zfos-1192g2.3.	Mitochondrial GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	0.973
ENSKMAP00000019562	pus7l	ENSKMAP00000019562	ENSKMAP00000016848	Si:zfos-1192g2.3.	Pseudouridine synthase 7 like.	0.776
ENSKMAP00000019562	rpl23	ENSKMAP00000019562	ENSKMAP00000021289	Si:zfos-1192g2.3.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.995
ENSKMAP00000019562	rpusd1	ENSKMAP00000019562	ENSKMAP00000023302	Si:zfos-1192g2.3.	RNA pseudouridine synthase domain containing 1.	0.863
gtpbp3	ENSKMAP00000019562	ENSKMAP00000005199	ENSKMAP00000019562	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Si:zfos-1192g2.3.	0.863
gtpbp3	gtpbp8	ENSKMAP00000005199	ENSKMAP00000027108	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	EngB-type G domain-containing protein.	0.950
gtpbp3	mrm3	ENSKMAP00000005199	ENSKMAP00000025730	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Mitochondrial rRNA methyltransferase 3a.	0.913
gtpbp3	mrpl17	ENSKMAP00000005199	ENSKMAP00000015003	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.861
gtpbp3	mrpl21	ENSKMAP00000005199	ENSKMAP00000027169	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Mitochondrial ribosomal protein L21.	0.910
gtpbp3	mrpl3	ENSKMAP00000005199	ENSKMAP00000002851	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Mitochondrial ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.870
gtpbp3	mtg1	ENSKMAP00000005199	ENSKMAP00000027038	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Mitochondrial GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	0.900
gtpbp3	pus7l	ENSKMAP00000005199	ENSKMAP00000016848	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Pseudouridine synthase 7 like.	0.782
gtpbp3	rpl23	ENSKMAP00000005199	ENSKMAP00000021289	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.841
gtpbp3	rpusd1	ENSKMAP00000005199	ENSKMAP00000023302	GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	RNA pseudouridine synthase domain containing 1.	0.849

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.926

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006006

Glucose metabolic process

6 of 12

2.19

3.99

3.96e-09

GO:0006096

Glycolytic process

5 of 8

2.29

3.67

4.16e-08

GO:0005975

Carbohydrate metabolic process

8 of 222

1.05

1.19

2.76e-06

GO:1901575

Organic substance catabolic process

6 of 137

1.14

1.16

7.46e-05

GO:0006094

Gluconeogenesis

2 of 6

2.02

1.13

0.0070

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

4 of 21

1.78

1.6

0.00040

GO:0050661

NADP binding

3 of 14

1.83

1.25

0.0031

GO:0051287

NAD binding

3 of 23

1.61

0.98

0.0089

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

2 of 8

1.89

0.7

0.0483

GO:0003824

Catalytic activity

11 of 1707

0.3

0.23

0.0483

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1047

0.48

0.36

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:941

Pentose phosphate pathway, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

10 of 25

2.1

6.46

2.44e-17

CL:943

Glycolysis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

8 of 13

2.28

6.22

1.78e-14

CL:947

Glyceraldehyde 3-phosphate dehydrogenase, active site, and Glycolysis

5 of 5

2.5

4.32

3.77e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 37

1.88

4.81

1.92e-14

map01200

Carbon metabolism

11 of 95

1.56

3.53

1.67e-15

map00030

Pentose phosphate pathway

5 of 24

1.81

2.7

3.99e-07

map01120

Microbial metabolism in diverse environments

11 of 248

1.14

1.7

1.42e-11

map01230

Biosynthesis of amino acids

7 of 123

1.25

1.61

6.54e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 849

0.52

0.33

0.0339

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 8

2.29

3.74

2.81e-08

KW-0312

Gluconeogenesis

2 of 4

2.19

1.01

0.0134

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02800

Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

3 of 3

2.5

1.95

0.00024

PF01081

KDPG and KHG aldolase

2 of 2

2.5

1.02

0.0136

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020831

Glyceraldehyde/Erythrose phosphate dehydrogenase family

3 of 3

2.5

1.73

0.00062

IPR020829

Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain

3 of 3

2.5

1.73

0.00062

IPR020828

Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain

3 of 3

2.5

1.73

0.00062

IPR013785

Aldolase-type TIM barrel

4 of 48

1.42

1.01

0.0046

IPR020830

Glyceraldehyde 3-phosphate dehydrogenase, active site

2 of 2

2.5

1.01

0.0144

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00846

Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

3 of 3

2.5

2.29

5.17e-05

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