trim71 protein (Kryptolebias marmoratus) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

trim71

Tripartite motif containing 71, E3 ubiquitin protein ligase. (828 aa)

Predicted Functional Partners:

LOC108237351

0.631

rnf181

0.614

eomes

0.497

LOC108248537

0.491

bbox1

0.478

LOC108235539

0.474

sall4

0.409

ubb

0.407

LOC108237971

0.407

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108235539	sall4	ENSKMAP00000018031	ENSKMAP00000003314	Lin-28 homolog A.	Spalt-like transcription factor 4.	0.613
LOC108235539	trim71	ENSKMAP00000018031	ENSKMAP00000029534	Lin-28 homolog A.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.474
LOC108237351	LOC108248537	ENSKMAP00000024746	ENSKMAP00000002722	Epithelial splicing regulatory protein 2.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.562
LOC108237351	eomes	ENSKMAP00000024746	ENSKMAP00000027754	Epithelial splicing regulatory protein 2.	Eomesodermin homolog b.	0.491
LOC108237351	trim71	ENSKMAP00000024746	ENSKMAP00000029534	Epithelial splicing regulatory protein 2.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.631
LOC108237971	trim71	ENSKMAP00000021597	ENSKMAP00000029534	Teneurin transmembrane protein 1.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.407
LOC108248537	LOC108237351	ENSKMAP00000002722	ENSKMAP00000024746	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Epithelial splicing regulatory protein 2.	0.562
LOC108248537	trim71	ENSKMAP00000002722	ENSKMAP00000029534	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.491
bbox1	trim71	ENSKMAP00000003690	ENSKMAP00000029534	Butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.478
eomes	LOC108237351	ENSKMAP00000027754	ENSKMAP00000024746	Eomesodermin homolog b.	Epithelial splicing regulatory protein 2.	0.491
eomes	trim71	ENSKMAP00000027754	ENSKMAP00000029534	Eomesodermin homolog b.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.497
rnf181	trim71	ENSKMAP00000014519	ENSKMAP00000029534	Ring finger protein 181.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.614
rnf181	ubb	ENSKMAP00000014519	ENSKMAP00000016559	Ring finger protein 181.	Uncharacterized protein.	0.666
sall4	LOC108235539	ENSKMAP00000003314	ENSKMAP00000018031	Spalt-like transcription factor 4.	Lin-28 homolog A.	0.613
sall4	trim71	ENSKMAP00000003314	ENSKMAP00000029534	Spalt-like transcription factor 4.	Tripartite motif containing 71, E3 ubiquitin protein ligase.	0.409
trim71	LOC108235539	ENSKMAP00000029534	ENSKMAP00000018031	Tripartite motif containing 71, E3 ubiquitin protein ligase.	Lin-28 homolog A.	0.474
trim71	LOC108237351	ENSKMAP00000029534	ENSKMAP00000024746	Tripartite motif containing 71, E3 ubiquitin protein ligase.	Epithelial splicing regulatory protein 2.	0.631
trim71	LOC108237971	ENSKMAP00000029534	ENSKMAP00000021597	Tripartite motif containing 71, E3 ubiquitin protein ligase.	Teneurin transmembrane protein 1.	0.407
trim71	LOC108248537	ENSKMAP00000029534	ENSKMAP00000002722	Tripartite motif containing 71, E3 ubiquitin protein ligase.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.491
trim71	bbox1	ENSKMAP00000029534	ENSKMAP00000003690	Tripartite motif containing 71, E3 ubiquitin protein ligase.	Butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1.	0.478

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051050

Positive regulation of transport

3 of 17

1.95

1.09

0.0078

GO:0006468

Protein phosphorylation

5 of 111

1.35

0.96

0.0052

GO:1902660

Negative regulation of glucose mediated signaling pathway

2 of 4

2.4

0.93

0.0200

GO:0000212

Meiotic spindle organization

2 of 5

2.3

0.91

0.0209

GO:0071988

Protein localization to spindle pole body

2 of 7

2.16

0.87

0.0239

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004707

MAP kinase activity

3 of 3

2.7

2.08

0.00015

GO:0005509

Calcium ion binding

4 of 39

1.71

1.59

0.00033

GO:0004674

Protein serine/threonine kinase activity

5 of 88

1.46

1.43

0.00023

GO:0106310

Protein serine kinase activity

4 of 70

1.46

1.17

0.0017

GO:0043167

Ion binding

11 of 1403

0.6

0.51

0.00019

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016459

Myosin complex

3 of 7

2.33

1.87

0.00030

GO:0005816

Spindle pole body

5 of 96

1.42

1.36

0.00030

GO:0016460

Myosin II complex

2 of 3

2.53

1.35

0.0034

GO:0044732

Mitotic spindle pole body

4 of 75

1.43

1.13

0.0020

GO:0005856

Cytoskeleton

7 of 283

1.09

1.03

0.00024

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:656

Myosin II complex, and Myosin I complex

3 of 6

2.4

1.78

0.00046

CL:917

Stress-activated MAPK cascade, and Activation of the AP-1 family of transcription factors

3 of 14

2.03

1.4

0.0019

CL:933

Activation of the AP-1 family of transcription factors, and Transcription factor, MADS-box

2 of 6

2.22

1.04

0.0119

CL:2383

Calmodulin-dependent protein kinase activity, and Synaptonemal structure

2 of 6

2.22

1.04

0.0119

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04070

Phosphatidylinositol signaling system

3 of 29

1.72

1.17

0.0039

map04011

MAPK signaling pathway - yeast

3 of 79

1.28

0.66

0.0327

map04111

Cell cycle - yeast

3 of 99

1.18

0.6

0.0413

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-198753

ERK/MAPK targets

3 of 8

2.28

1.79

0.00041

MAP-450282

MAPK targets/ Nuclear events mediated by MAP kinases

3 of 10

2.18

1.73

0.00048

MAP-881907

Gastrin-CREB signalling pathway via PKC and MAPK

2 of 2

2.7

1.73

0.00069

MAP-198725

Nuclear Events (kinase and transcription factor activation)

3 of 11

2.14

1.72

0.00048

MAP-187037

Signaling by NTRK1 (TRKA)

3 of 12

2.1

1.7

0.00048

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016459

Myosin complex

3 of 9

2.22

1.56

0.0011

GOCC:0016460

Myosin II complex

2 of 2

2.7

1.11

0.0096

GOCC:0071341

Medial cortical node

2 of 7

2.16

0.93

0.0182

GOCC:0005816

Spindle pole body

3 of 45

1.53

0.84

0.0171

GOCC:0032153

Cell division site

4 of 109

1.27

0.81

0.0108

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0106

Calcium

5 of 24

2.02

3.04

2.68e-07

KW-0723

Serine/threonine-protein kinase

4 of 29

1.84

2.05

3.63e-05

KW-0418

Kinase

6 of 171

1.25

1.36

3.63e-05

KW-0547

Nucleotide-binding

5 of 327

0.89

0.59

0.0111

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018247

EF-Hand 1, calcium-binding site

5 of 17

2.17

3.06

5.59e-07

IPR002048

EF-hand domain

5 of 19

2.12

3.02

5.59e-07

IPR011992

EF-hand domain pair

5 of 21

2.08

2.98

5.59e-07

IPR008271

Serine/threonine-protein kinase, active site

5 of 60

1.62

1.82

4.22e-05

IPR000719

Protein kinase domain

5 of 77

1.51

1.58

0.00011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00054

EF-hand, calcium binding motif

5 of 10

2.4

4.09

7.78e-09

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 34

1.65

1.08

0.0054

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