node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL4 | MEE15 | Q8LGH4 | A0A1P8AXC3 | Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin- protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin- protein ligase complex which mediates ubiquit [...] | Major facilitator superfamily protein. | 0.432 |
CUL4 | VPS15 | Q8LGH4 | Q9M0E5 | Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin- protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin- protein ligase complex which mediates ubiquit [...] | Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. | 0.770 |
F10A5.7 | MEE15 | A4FVS5 | A0A1P8AXC3 | At1g75730. | Major facilitator superfamily protein. | 0.929 |
F2G1.18 | MEE15 | Q9SIK4 | A0A1P8AXC3 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Major facilitator superfamily protein. | 0.405 |
MEE15 | CUL4 | A0A1P8AXC3 | Q8LGH4 | Major facilitator superfamily protein. | Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin- protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin- protein ligase complex which mediates ubiquit [...] | 0.432 |
MEE15 | F10A5.7 | A0A1P8AXC3 | A4FVS5 | Major facilitator superfamily protein. | At1g75730. | 0.929 |
MEE15 | F2G1.18 | A0A1P8AXC3 | Q9SIK4 | Major facilitator superfamily protein. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.405 |
MEE15 | MTN1 | A0A1P8AXC3 | Q9T0I8 | Major facilitator superfamily protein. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy). | 0.785 |
MEE15 | MTN2 | A0A1P8AXC3 | Q7XA67 | Major facilitator superfamily protein. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in both 5'- methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S- ribosylhomocysteine, respectively. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. | 0.785 |
MEE15 | VPS15 | A0A1P8AXC3 | Q9M0E5 | Major facilitator superfamily protein. | Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. | 0.740 |
MTN1 | MEE15 | Q9T0I8 | A0A1P8AXC3 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy). | Major facilitator superfamily protein. | 0.785 |
MTN1 | MTN2 | Q9T0I8 | Q7XA67 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy). | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in both 5'- methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S- ribosylhomocysteine, respectively. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. | 0.904 |
MTN2 | MEE15 | Q7XA67 | A0A1P8AXC3 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in both 5'- methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S- ribosylhomocysteine, respectively. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. | Major facilitator superfamily protein. | 0.785 |
MTN2 | MTN1 | Q7XA67 | Q9T0I8 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in both 5'- methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S- ribosylhomocysteine, respectively. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1; Enzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy). | 0.904 |
VPS15 | CUL4 | Q9M0E5 | Q8LGH4 | Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. | Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin- protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin- protein ligase complex which mediates ubiquit [...] | 0.770 |
VPS15 | MEE15 | Q9M0E5 | A0A1P8AXC3 | Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. | Major facilitator superfamily protein. | 0.740 |