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NIMIN1 protein (Arabidopsis thaliana) - STRING interaction network
"NIMIN1" - Protein NIM1-INTERACTING 1 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NIMIN1Protein NIM1-INTERACTING 1; NIMIN1 modulates PR gene expression according the following model- NPR1 forms a ternary complex with NIMIN1 and TGA factors upon SAR induction that binds to a positive regulatory cis-element of the PR-1 promoter, termed LS7. This leads to PR-1 gene induction. NIMIN1 decreases transcriptional activation, possibly through its EAR motif, which results in fine-tuning of PR-1 gene expression; Belongs to the NPR1-interactor family (142 aa)    
Predicted Functional Partners:
NIMIN-2
Protein NIM1-INTERACTING 2; Encodes a kinase that physically interacts with NPR1/NIM1 (122 aa)
     
   
  0.979
NPR1
Regulatory protein (NPR1); May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA- dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction [...] (593 aa)
     
 
  0.954
NIMIN-3
Protein NIM1-INTERACTING 3; Encodes a kinase that physically interacts with NPR1/NIM1; Belongs to the NPR1-interactor family (112 aa)
           
  0.953
WRKY38
Probable WRKY transcription factor 38; Transcription factor. Interacts specifically with the W box (5’-(T)TGAC[CT]-3’), a frequently occurring elicitor- responsive cis-acting element (By similarity) (289 aa)
     
   
  0.871
AHBP-1B
bZIP transcription factor family protein; Transcriptional activator that binds specifically to the DNA sequence 5’-TGACG-3’. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as-1 element of PR-1 promoter is salicylic acid- inducible and mediated by NPR1. Could also bind to the C-boxes (5’-ATGACGTCAT-3’) with high affinity (330 aa)
       
 
  0.866
NPR3
Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens (586 aa)
     
 
  0.863
TGA6
TGACG motif-binding factor 6; Transcriptional activator that binds specifically to the DNA sequence 5’-TGACG-3’. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5’-TGACGTGG-3’) another cis-acting element found in plant histone promoters (By similarity); Belongs to the bZIP family (355 aa)
       
 
  0.834
NUDT6
Nudix hydrolase homolog 6; Encodes a protein with NADH pyrophosphatase activity. Although this protein was also shown to have ADP-ribose diphosphatase activity in vitro, mutant analyses suggest that NUDX6 is involved in NADH metabolism in vivo; Belongs to the Nudix hydrolase family (283 aa)
     
   
  0.783
WRKY70
Member of WRKY Transcription Factor; Group III. Function as activator of SA-dependent defense genes and a repressor of JA-regulated genes. WRKY70-controlled suppression of JA-signaling is partly executed by NPR1 (294 aa)
     
   
  0.761
PAD4
alpha/beta-Hydrolases superfamily protein; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe-associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS- LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response [...] (541 aa)
     
   
  0.689
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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