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STRINGSTRING
ERG28 protein (Arabidopsis thaliana) - STRING interaction network
"ERG28" - Homolog of yeast ergosterol28 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ERG28Homolog of yeast ergosterol28 (ERG28); Involved in biological_process unknown; Located in endomembrane system, integral to membrane; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Erg28-like (InterPro-IPR005352); Has 223 Blast hits to 223 proteins in 105 species- Archae - 0; Bacteria - 0; Metazoa - 67; Fungi - 94; Plants - 48; Viruses - 0; Other Eukaryotes - 14 (source- NCBI BLink) (129 aa)    
Predicted Functional Partners:
CYP51G1
Sterol 14-demethylase; Involved in sterol biosynthesis. Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta- 8,14,24(28)-trien-3 beta-ol (488 aa)
     
 
  0.984
SMO2-2
Sterol 4-alpha-methyl-oxidase 2-2; Non-heme iron oxygenase involved in sterols biosynthesis. 24-ethylidenelophenol and 24-ethyllophenol are the preferred substrates (272 aa)
     
 
  0.970
SQS1
Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate- presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway (410 aa)
     
 
  0.962
DWF5
Ergosterol biosynthesis ERG4/ERG24 family; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). Lesions in the gene coding for the enzyme cause dwarfism; Belongs to the ERG4/ERG24 family (432 aa)
     
 
  0.954
SMT2
24-methylenesterol C-methyltransferase 2; Encodes a sterol-C24-methyltransferases involved in sterol biosynthesis. Mutants display altered sterol composition, serrated petals and sepals and altered cotyledon vascular patterning as well as ectopic endoreduplication. This suggests that suppression of endoreduplication is important for petal morphogenesis and that normal sterol composition is required for this suppression (361 aa)
       
 
  0.931
FK
Ergosterol biosynthesis ERG4/ERG24 family; Reduces the C14=C15 double bond of 4,4-dimethyl- cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol. Required for cell division and expansion and is involved in proper organization of the embryo (369 aa)
     
 
  0.931
SMT1
Cycloartenol-C-24-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family (336 aa)
       
 
  0.925
AT3G02590
Putative Delta(7)-sterol-C5(6)-desaturase 2; Fatty acid hydroxylase superfamily protein; Its function is described as oxidoreductase activity, C-5 sterol desaturase activity, iron ion binding; Involved in oxidation reduction, sterol biosynthetic process, fatty acid biosynthetic process; Located in endoplasmic reticulum; Expressed in 8 plant structures; Expressed during 4 anthesis, petal differentiation and expansion stage; Contains the following InterPro domains- Fatty acid hydroxylase (InterPro-IPR006694); BEST Arabidopsis thaliana protein match is- sterol 1 (TAIR-AT3G02580.1); Has 24 [...] (279 aa)
     
 
  0.920
STE1
Delta(7)-sterol-C5(6)-desaturase 1; Brassinosteroid biosynthetic enzyme, catalyzes delta7 sterol C-5 desaturation step. Mutant has dwarf phenotype; Belongs to the sterol desaturase family (281 aa)
     
 
  0.920
CAS1
Cycloartenol synthase 1; Converts oxidosqualene to cycloartenol and 1% parkeol. Involved in plastid biogenesis. Essential for the male gametophyte function; Belongs to the terpene cyclase/mutase family (759 aa)
     
 
  0.895
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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