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HOP2 protein (Arabidopsis thaliana) - STRING interaction network
"HOP2" - Arabidopsis Hop2 homolog in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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HOP2Arabidopsis Hop2 homolog; Involved in bivalent formation and segregation of homologous chromosomes in meiosis (226 aa)    
Predicted Functional Partners:
ATMND1
Meiotic nuclear division protein 1-like protein; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1/LIM15- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (230 aa)
     
 
  0.997
ATSPO11-1
Meiotic recombination protein SPO11-1; Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed-11157765, PubMed-17018031, PubMed-17965269, PubMed-26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed-26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed-11157765, PubMed-17018031, PubMed-17965269, PubMed-26917763) (362 aa)
     
 
  0.942
RAD51
DNA repair protein RAD51-like 1; Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis (342 aa)
     
 
  0.860
DMC1
DISRUPTION OF MEIOTIC CONTROL 1; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (344 aa)
     
 
  0.860
PRA1.B5
PRA1-like protein B5; May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments (223 aa)
           
  0.802
PRD3
Putative recombination initiation defects 3 (449 aa)
     
   
  0.747
SPO11-2
Sporulation 11-2; Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed-17018031, PubMed-17965269, PubMed-26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed-26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed-17018031, PubMed-17965269, PubMed-26917763) (383 aa)
     
 
  0.742
ASY1
ASYNAPTIC 1 (596 aa)
           
  0.741
AT5G46140
Uncharacterized protein (289 aa)
           
  0.734
RHL2
ROOT HAIRLESS 2; Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Involved in cell-elongation processes (427 aa)
     
 
  0.705
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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