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HOP2 protein (Arabidopsis thaliana) - STRING interaction network
"HOP2" - Encodes the Arabidopsis Hop2 homologue. In other species, Hop2 is proposed to be involved in inter-homolog bias in double strand break repair in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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HOP2Encodes the Arabidopsis Hop2 homologue. In other species, Hop2 is proposed to be involved in inter-homolog bias in double strand break repair (226 aa)    
Predicted Functional Partners:
ATMND1
A homolog of yeast, mouse and human mnd1delta protein. Null mutants exhibit normal vegetative and flower development; however, during prophase I, chromosomes become fragmented resulting in random distribution of the fragments between polyads. Both male and female meiosis are defective and strong accumulation of AtRAD51 was observed in the inflorescence nuclei of mutant plants. Similarly to its yeast and animal homologues, AtMnd1 might play a role in DSB repair during meiosis (230 aa)
     
 
  0.999
DMC1
Meiotic recombination protein DMC1 homolog; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Mediates interhomolog recombination during meiosis (344 aa)
     
 
  0.943
ATSPO11-1
Spo11/DNA topoisomerase VI, subunit A protein; Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that [...] (362 aa)
     
 
  0.902
RAD51C
RAS associated with diabetes protein 51C; Encodes a protein similar to RAD51C involved in double stranded break repair via homologous recombination. Sensitive to DSB induced by Mitomycin C and gamma irradiation, interacts with Atxrcc3 in yeast two-hybrid assay. Required for female meiosis but not critical for mitosis under normal conditions; Belongs to the RecA family. RAD51 subfamily (387 aa)
     
 
  0.864
RAD51
RAS associated with diabetes protein 51; Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis (342 aa)
     
 
  0.862
ASY1
DNA-binding HORMA family protein; Required for normal meiosis in male and female gametophytes. Plays a crucial role in coordinating the activity of DMC1, a key member of the homologous recombination machinery. Acts at the interface between the developing chromosome axes and the recombination machinery to ensure DMC1- mediated interhomolog recombination (596 aa)
     
   
  0.846
RNR1
Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen. Involved in chloroplast division (816 aa)
     
   
  0.770
AT1G32530
RING/U-box superfamily protein; Its function is described as zinc ion binding; Expressed in 23 plant structures; Expressed during 14 growth stages; Contains the following InterPro domains- Zinc finger, RING-type (InterPro-IPR001841); BEST Arabidopsis thaliana protein match is- RING/U-box superfamily protein (TAIR-AT2G35330.1); Has 39408 Blast hits to 25935 proteins in 1821 species- Archae - 329; Bacteria - 4848; Metazoa - 19615; Fungi - 2599; Plants - 1752; Viruses - 136; Other Eukaryotes - 10129 (source- NCBI BLink) (711 aa)
       
      0.752
MSH4
DNA mismatch repair protein MSH4; Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation; Belongs to the DNA mismatch repair MutS family (792 aa)
           
  0.747
AHP1
Encodes AHP1, one of the six Arabidopsis thaliana histidine phosphotransfer proteins (AHPs). AHPs function as redundant positive regulators of cytokinin signaling. Members of the AHP gene family include- AT3G21510 (AHP1), AT3G29350 (AHP2), AT5G39340 (AHP3), AT3G16360 (AHP4), AT1G03430 (AHP5) and AT1G80100 (AHP6) (154 aa)
           
  0.747
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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