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STRINGSTRING
RAD23A protein (Arabidopsis thaliana) - STRING interaction network
"RAD23A" - Rad23 UV excision repair protein family in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
RAD23ARad23 UV excision repair protein family; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity); Belongs to the RAD23 family (368 aa)    
Predicted Functional Partners:
PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native prote [...] (721 aa)
       
  0.997
RAD4
DNA repair protein Rad4 family; May have a role in the nucleotide excision repair (NER) pathway (865 aa)
       
  0.996
RPN10
26S proteasome non-ATPase regulatory subunit 4 homolog; Plays a role in maintaining the structural integrity of the 19S regulatory particle (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and [...] (386 aa)
     
 
  0.995
DSK2
Ubiquitin domain-containing protein DSK2b; Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (551 aa)
     
 
  0.992
DDI1
Uncharacterized protein At3g13235; Ubiquitin family protein; Its function is described as aspartic-type endopeptidase activity; Involved in response to cadmium ion; Located in cytosol, nucleus; Expressed in 24 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro-IPR000449), Peptidase aspartic (InterPro-IPR021109), Ubiquitin subgroup (InterPro-IPR019956), Peptidase aspartic, eukaryotic predicted (InterPro-IPR019103), Ubiquitin-associated/translation elongation factor EF [...] (414 aa)
     
 
  0.984
CDC48
Encodes a cell division cycle protein, a member of AAA-type ATPases gene family. Expressed throughout the plant in regions of cell division. Within the cell, sub-cellular localization varies depending on the stage of the cell cycle.Mutants in which the expression of CDC48A is altered show defects in cytokinesis, cell expansion and cell differentiation (809 aa)
     
  0.984
AT5G15400
Probable ubiquitin conjugation factor E4; Ubiquitin-protein ligase that may function as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chain assembly on substrates monoubiquitinated by another E3 ubiquitin ligase (1038 aa)
     
 
  0.983
RPT2a
26S proteasome regulatory subunit 4 homolog A; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Is required for the maintenance of postembryonic root and shoot meristems. Has a specific role in the regulation of organs size (443 aa)
     
  0.981
RPT2b
26S proteasome regulatory subunit 4 homolog B; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (443 aa)
     
  0.981
CEN1
Probable calcium-binding protein CML20; Potential calcium sensor (169 aa)
     
  0.973
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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