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RAD23A protein (Arabidopsis thaliana) - STRING interaction network
"RAD23A" - RADIATION SENSITIVE23A in Arabidopsis thaliana
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RAD23ARADIATION SENSITIVE23A; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity) (368 aa)    
Predicted Functional Partners:
RPN10
Regulatory particle non-ATPase 10; Plays a role in maintaining the structural integrity of the 19S regulatory particule (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and DSK2s. Plays a role [...] (386 aa)
     
 
  0.990
AT2G17190
Ubiquilin; Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for ’Lys-48’-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (538 aa)
     
 
  0.963
RPN1B
26S proteasome regulatory subunit S2 1B; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (891 aa)
     
 
  0.961
RAD4
DNA repair protein Rad4 family; May have a role in the nucleotide excision repair (NER) pathway (865 aa)
       
 
  0.961
RPN1A
26S proteasome regulatory subunit N1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). Required during embryogenesis (PubMed-16169895). Required for optimal plant growth and stress responses (PubMed-19605416). Required for innate immunity (PubMed-22577987) (891 aa)
     
 
  0.955
PNG1
peptide-N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite [...] (721 aa)
       
 
  0.955
AT4G08140
Uncharacterized protein (84 aa)
     
 
  0.954
DDI1
DNA-damage inducible 1 (414 aa)
     
 
  0.949
AT5G15400
U-box domain-containing protein; Ubiquitin-protein ligase that may function as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chain assembly on substrates monoubiquitinated by another E3 ubiquitin ligase (1038 aa)
     
 
  0.949
RPT2b
Regulatory particle AAA-ATPase 2b; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (443 aa)
     
 
  0.907
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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